The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study
Abstract
OBJECTIVE: Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans. METHOD: Ten Vietnam combat veterans with chronic PTSD and severe trauma-related nightmares each received prazosin and placebo in a 20-week double-blind crossover protocol. RESULTS: Prazosin (mean dose=9.5 mg/day at bedtime, SD=0.5) was superior to placebo for the three primary outcome measures: scores on the 1) recurrent distressing dreams item and the 2) difficulty falling/staying asleep item of the Clinician-Administered PTSD Scale and 3) change in overall PTSD severity and functional status according to the Clinical Global Impression of change. Total score and symptom cluster scores for reexperiencing, avoidance/numbing, and hyperarousal on the Clinician-Administered PTSD Scale also were significantly more improved in the prazosin condition, and prazosin was well tolerated. CONCLUSIONS: These data support the efficacy of prazosin for nightmares, sleep disturbance, and other PTSD symptoms.
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Cites
The development of a Clinician-Administered PTSD Scale
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CSF Norepinephrine Concentrations in Posttraumatic Stress Disorder
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α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function
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Self-citationRaskind, M. A., Dobie, D. J., Kanter, E. D., Petrie, E. C., Thompson, C. E., & Peskind, E. R. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n0208 · Cited by 154
Self-citationWoodward, S. H., Arsenault, N. J., Murray, C. F., & Bliwise, D. L. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00917-3 · Cited by 153
Prazosin Reduces Nightmares in Combat Veterans With Posttraumatic Stress Disorder
Raskind, M. A., Thompson, C. E., Petrie, E. C., Dobie, D. J., Rein, R. J., Hoff, D. J., McFall, M., & Peskind, E. R. (2002) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v63n0705 · Cited by 146
Self-citationVythilingam, M., Anderson, G. M., Owens, M. J., Halaszynski, T. M., Bremner, J. D., Carpenter, L. L., Heninger, G. R., Nemeroff, C. B., & Ds, C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.11.4138 · Cited by 52
Cited by
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
The sleep-deprived human brain
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.55 · Cited by 1,200
Katzman, M. A., Bleau, P., Blier, P., Chokka, P., Kjernisted, K., Van Ameringen, M., & the Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-s1-s1 · Cited by 1,090
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052
“Given nocturnally, patients with combat PTSD and civilian PTSD both demonstrate a restoration of REM sleep, together with decreases in trauma-dream symptomatology (Calohan et al 2010, Raskind et al 2007, Raskind et al 2003, Taylor et al 2008).”
Background
Metadata
- Authors
- Raskind, M. A., Peskind, E. R., Kanter, E. D., Petrie, E. C., Radant, A., Thompson, C. E., Dobie, D. J., Hoff, D., Rein, R. J., Straits-Tröster, K., Thomas, R. G., & McFall, M. M.
- Venue
- American Journal of Psychiatry
- Published
- 2003-02-01
- Volume
- 160
- Issue
- 2
- Pages
- 371-373
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2170933900
- Cited by
- 607
- References
- 11
- FWCI
- 28.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Raskind, M. A., Peskind, E. R., Kanter, E. D., Petrie, E. C., Radant, A., Thompson, C. E., Dobie, D. J., Hoff, D., Rein, R. J., Straits-Tröster, K., Thomas, R. G., & McFall, M. M. (2003). Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.160.2.371
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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