The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Dysregulation of Arousal and Amygdala-Prefrontal Systems in Paranoid Schizophrenia
Abstract
OBJECTIVE: The authors investigated impaired differentiation of limbic-prefrontal systems by autonomic arousal in schizophrenia. It was predicted that paranoid patients would be distinguished by a disjunction of hyperarousal but reduced amygdala and medial prefrontal activity relative to both healthy comparison subjects and patients with nonparanoid schizophrenia. METHOD: Pictures depicting facial expressions of fear were presented to 27 schizophrenia patients (13 paranoid, 14 nonparanoid) and 22 matched healthy comparison subjects in an implicit perception task to evoke limbic activity. Simultaneous functional magnetic resonance imaging and skin conductance arousal recordings were acquired during presentation of faces expressing fear or neutral emotion. Responses to fear stimuli were further examined by contrasting those that were associated with a skin conductance response ("with arousal") and those that were not ("without arousal"). RESULTS: In the comparison subjects, arousal dissociated amygdala/medial prefrontal ("visceral") networks and hippocampus/lateral prefrontal ("context") networks for fear perception. Excessive arousal responses were elicited in the schizophrenia subjects, but there was an associated reduction in amygdala/medial prefrontal activity. This disjunction was pronounced in paranoid patients relative to both healthy subjects and nonparanoid patients. Paranoid patients also showed a relatively greater prefrontal deficit for "without-arousal" responses. CONCLUSIONS: This is the first study to reveal a functional disconnection in autonomic and central systems for processing threat-related signals in patients with paranoid schizophrenia. Paranoid cognition may reflect an internally generated cycle of misattribution regarding incoming fear signals due to a breakdown in the regulation of these systems.
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“This in turn can intensify symptoms of hypervigilance and paranoia69.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [69]
In the citing paper
“In a group of paranoid SCZ patients (DSM IV criteria), with persistently high arousal states, the lack of engagement between these brain regions may lead to preservation and exacerbation of arousal responses and a shift in sympathovagal balance influencing the heart28,69.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [69]
In the citing paper
“It is postulated that the relationship with HRV may be mediated by the reduced activity in the amygdala–prefrontal circuits that have been described in SCZ69.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [69]
Citations
Cites
(1996) · Cited by 3,692
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
The psychology of fear and stress
(1988) · Choice Reviews Online · doi:10.5860/choice.26-2399 · Cited by 3,133
Robins, L. N. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800360017003 · Cited by 2,909
The somatic marker hypothesis and the possible functions of the prefrontal cortex
Damasio, A. R. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0125 · Cited by 2,847 · cited 2×
“The concomitant lack of “with-arousal” medial prefrontal engagement suggests that this region cannot undertake its usual role in regulating amygdala-autonomic function, leading to a perseveration and exacerbation of arousal responses (18, 19).”
BackgroundA differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
Topography Of Cognition: Parallel Distributed Networks In Primate Association Cortex
Goldman‐Rakic, P. S. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001033 · Cited by 1,658
A specific neural substrate for perceiving facial expressions of disgust
Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J., Bullmore, E. T., Perrett, D. I., Rowland, D., Williams, S. C. R., et al. (1997) · Nature · doi:10.1038/39051 · Cited by 1,609
Self-citationBechara, A., Tranel, D., Damasio, H., Adolphs, R., Rockland, C., & Damasio, A. R. (1995) · Science · doi:10.1126/science.7652558 · Cited by 1,400
Dementia: The Estimation of Premorbid Intelligence Levels Using the New Adult Reading Test
Nelson, H. E., & O’Connell, A. (1978) · Cortex · doi:10.1016/s0010-9452(78)80049-5 · Cited by 1,120
Emotion recognition via facial expression and affective prosody in schizophrenia
Edwards, J., Jackson, H. J., & Pattison, P. E. (2002) · Clinical Psychology Review · doi:10.1016/s0272-7358(02)00130-7 · Cited by 714
Drevets, W. C., & Raichle, M. E. (1998) · Cognition & Emotion · doi:10.1080/026999398379646 · Cited by 702
Facial expressions of emotions and schizophrenia: a review.
Mandal, M., Pandey, R., & Prasad, A. B. (1998) · Schizophrenia bulletin · doi:10.1093/oxfordjournals.schbul.a033335 · Cited by 563
LATERALIZED TEMPORAL‐LIMBIC DYSFUNCTION AND PSYCHOPATHOLOGY*
Flor-Henry, P. (1976) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1976.tb25541.x · Cited by 524
Generic brain activation mapping in functional magnetic resonance imaging: A nonparametric approach
Brammer, M. J., Bullmore, E. T., Simmons, A., Williams, S., Grasby, P. M., Howard, R. J., Woodruff, P. W. R., & Rabe‐Hesketh, S. (1997) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(97)00135-5 · Cited by 470
Self-citationKring, A. M., & Neale, J. M. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.2.249 · Cited by 374
Temporolimbic Volume Reductions in Schizophrenia
Gur, R. E., Turetsky, B. I., Cowell, P. E., Finkelman, C., Maany, V., Grossman, R. I., Arnold, S. E., Bilker, W. B., & Gur, R. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.8.769 · Cited by 355
Hippocampus-amygdala volumes and psychopathology in chronic schizophrenia
Bogerts, B., Lieberman, J. A., Ashtari, M., Bilder, R. M., Degreef, G., Lerner, G., Johns, C. A., & Masiar, S. J. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90289-p · Cited by 338
Phillips, M. L., Williams, L. M., Senior, C., Bullmore, E. T., Brammer, M. J., Andrew, C., Williams, S., & David, A. S. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00031-1 · Cited by 302
Self-citationWilliams, L. M., Phillips, M. L., Brammer, M. J., Skerrett, D., Lagopoulos, J., Rennie, C., Bahramali, H., Olivieri, G., David, A. S., Peduto, A., et al. (2001) · NeuroImage · doi:10.1006/nimg.2001.0904 · Cited by 300
Self-citationDecomposing skin conductance into tonic and phasic components
Lim, C. L., RENNIE, C. J., Barry, R. J., Bahramali, H., Lazzaro, I., Manor, B. R., & Gordon, E. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(96)00713-1 · Cited by 226
Self-citationAtypical antipsychotic agents: A critical review
Worrel, J. A., Marken, P. A., Beckman, S. E., & Ruehter, V. (2000) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/57.3.238 · Cited by 194
Habituation of phasic and tonic components of the orienting reflex
Barry, R. J., & Sokolov, E. N. (1993) · International Journal of Psychophysiology · doi:10.1016/0167-8760(93)90093-5 · Cited by 169
Quantitative trait locus analysis of contextual fear conditioning in mice
Wehner, J. M., Radcliffe, R. A., Rosmann, S. T., Christensen, S. C., Rasmussen, D. L., Fulker, D. W., & Wiles, M. (1997) · Nature Genetics · doi:10.1038/ng1197-331 · Cited by 163
Phillips, M. L., Senior, C., & David, A. S. (2000) · Psychological Medicine · doi:10.1017/s0033291799001397 · Cited by 127
Self-citationKimberg, D. Y., Aguirre, G. K., Lease, J., & D’Esposito, M. (2001) · Human Brain Mapping · doi:10.1002/1097-0193(200104)12:4 · Cited by 102
Self-citationNeuropsychological differences among empirically derived clinical subtypes of schizophrenia.
Hill, S. K., Ragland, J. D., Gur, R. C., & Gur, R. E. (2001) · Neuropsychology · doi:10.1037/0894-4105.15.4.492 · Cited by 56
Impaired Autonomic Nervous System Habituation in Those at Genetic Risk for Schizophrenia
Hollister, J. M. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950070044009 · Cited by 31
Lindström, E. M., Öhlund, L. S., Lindström, L., & Öhman, A. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90078-h · Cited by 21
Electrodermal responsivity distinguishes ERP activity and symptom profile in schizophrenia
Williams, L. M., Bahramali, H., Hemsley, D. R., Harris, A. W. F., Brown, K. J., & Gordon, E. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00368-1 · Cited by 16
Self-citationSchiffer, R., Sigal, M., & Mintz, M. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02845-4 · Cited by 14
An, X., Bandler, R., �ng�r, D., & Price, J. L. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981130)401:4
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Sergerie, K., Chochol, C., & Armony, J. L. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.12.002 · Cited by 917
Hypothalamic Abnormalities in Schizophrenia: Sex Effects and Genetic Vulnerability
Goldstein, J. M., Seidman, L. J., Makris, N., Ahern, T., O’Brien, L. M., Caviness, V. S., Kennedy, D. N., Faraone, S. V., & Tsuang, M. T. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.027 · Cited by 542
Emotional Response Deficits in Schizophrenia: Insights From Affective Science
Kring, A. M., & Moran, E. K. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn071 · Cited by 458
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Metadata
- Authors
- Williams, L. M., Das, P., Harris, A. W. F., Liddell, B. B., Brammer, M. J., Olivieri, G., Skerrett, D., Phillips, M. L., David, A. S., Peduto, A., & Gordon, E.
- Affiliations
- The University of Sydney (AU)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2004-03-01
- Volume
- 161
- Issue
- 3
- Pages
- 480-489
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2137483563
- Cited by
- 337
- References
- 33
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 23 · 2015: 20 · 2014: 6 · 2013: 14 · 2012: 30
- FWCI
- 15.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- paranoid schizophrenia, autonomic arousal, skin conductance, amygdala, medial prefrontal cortex, fear perception, hyperarousal, threat processing, functional disconnection
- MeSH terms
- Adult, Amygdala, Arousal, Autonomic Nervous System, Facial Expression, Fear, Female, Galvanic Skin Response, Hippocampus, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Pattern Recognition, Visual, Psychiatric Status Rating Scales, Reference Values, Schizophrenia, Paranoid, Social Perception, Prefrontal Cortex
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