The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Medication Treatment of Different Types of Alcoholism
Open accessAbstract
Alcoholism remains a serious cause of morbidity and mortality despite progress through neurobiological research in identifying new pharmacological strategies for its treatment. Drugs that affect neural pathways that modulate the activity of the cortico-mesolimbic dopamine system have been shown to alter drinking behavior, presumably because this dopaminergic system is closely associated with rewarding behavior. Ondansetron, naltrexone, topiramate, and baclofen are examples. Subtyping alcoholism in adults into an early-onset type, with chronic symptoms and a strong biological predisposition to the disease, and a late-onset type, typically brought on by psychosocial triggers and associated with mood symptoms, may help in the selection of optimal therapy. Emerging adults with binge drinking patterns also might be aided by selective treatments. Although preliminary work on the pharmacogenetics of alcoholism and its treatment has been promising, the assignment to treatment still depends on clinical assessment. Brief behavioral interventions that encourage the patient to set goals for a reduction in heavy drinking or abstinence also are part of optimal therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“To prevent the first drink, however, the psychological or cognitive threat is thought to be dominant and active and thus dissuade use [5], [6], [7].”
From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Drug Dependence, a Chronic Medical Illness
McLellan, A. T., Lewis, D. C., O'Brien, C. P., & Kleber, H. D. (2000) · JAMA · doi:10.1001/jama.284.13.1689 · Cited by 2,622 · cited 1×
“Alcohol dependence often follows a chronic, relapsing course (2) similar to other medical disorders, such as diabetes.”
Allelic Variation of Human Serotonin Transporter Gene Expression
Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., & Lesch, K. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66062621.x · Cited by 2,221
Neurogenetic Adaptive Mechanisms in Alcoholism
Cloninger, C. R. (1987) · Science · doi:10.1126/science.2882604 · Cited by 2,203 · cited 1×
“(9), there are at least two different subtypes of alcoholism.”
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930
Self-citationHasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645
Finite Mixture Modeling with Mixture Outcomes Using the EM Algorithm
Muthén, B., & Shedden, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00463.x · Cited by 1,498 · cited 1×
“Those who drink severely or binge drink between the ages of 18 and 24 are more likely to progress to alcohol abuse or dependence diagnoses (29, 30).”
Wechsler, H., Lee, J. E., Kuo, M., Seibring, M., Nelson, T. F., & Lee, H. (2002) · Journal of American College Health · doi:10.1080/07448480209595713 · Cited by 1,457 · cited 4×
“One-fourth of college students report drinking-related academic problems, such as missing classes, falling behind, performing poorly on examinations and papers, and getting lower grades (19, 26, 27).”
InfluentialVolume, I. I. (2017) · Institute for Social Research eBooks · doi:10.3998/2027.42/139710 · Cited by 1,369
The Alcohol Use Disorders Identification Test (AUDIT): A review of recent research
Reinert, D. F., & Allen, J. P. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02534.x · Cited by 1,143
Hingson, R., Heeren, T., Winter, M., & Wechsler, H. (2005) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.26.021304.144652 · Cited by 1,102
Research works printed but not linked: 10
- Johnson BA , DiClemente CC , Ait-Daoud N , Stoks SM : Brief Behavioral Compliance Enhancement Treatment (BBCET) manual, in Handbook of Clinical Alcoholism Treatment. Edited by , Johnson BA , Ruiz P , Galanter M . Baltimore, Lippincott Williams & Wilkins, 2003, pp 282–301
- Pettinati HM, 2004, Medical Management Treatment Manual: A Clinical Research Guide for Medically Trained Clinicians Providing Pharmacotherapy as Part of the Treatment for Alcohol Dependence. COMBINE Monograph Series, vol 2 (DHHS Publication No. 04–5289)
- 2000, American Psychiatric Association
- Johnson BA, 2000, Alcohol Clin Exp Res, 24, 1597
- Engs RC, 1996, J Alcohol Drug Educ, 41, 13
- Blow FC, 2002, Alcohol Res Health, 26, 308
- Thase ME, 2001, J Clin Psychiatry, 62, 32
- Hemby SE , Johnson BA , Dworkin SI : Neurobiological basis of drug reinforcement, in Drug Addiction and Its Treatment: Nexus of Neuroscience and Behavior. Edited by , Johnson BA , Roache JD . Philadelphia, Lippincott-Raven, 1997, pp 137–169
- National Institute on Alcohol Abuse and Alcoholism: Helping Patients Who Drink Too Much: A Clinician's Guide: Updated 2005 Edition (NIH Publication No. 07–3769). Bethesda, Md, US Department of Health and Human Services, 2005
- Ait-Daoud N , Johnson BA : Medications for the treatment of alcoholism, in Handbook of Clinical Alcoholism Treatment. Edited by , Johnson BA , Ruiz P , Galanter M . Baltimore, Lippincott Williams & Wilkins, 2003, pp 119–130
Cited by
Sorted by citations
Items 101–152 of 152
The effects of binge drinking on healthy and diseased livers
Rumbolt, C., & Minuk, G. Y. (2021) · Canadian Liver Journal · doi:10.3138/canlivj-2020-0037 · Cited by 1
Recent advances in the pharmacotherapy of psychiatric disorders
Woo, Y. S., & Bahk, W. (2011) · Journal of Korean Medical Association · doi:10.5124/jkma.2011.54.10.1061 · Cited by 1
Patiño, D. R., Dariana Pereira, R., & Restrepo, J. C. (2016) · Revista Colombiana de Gastroenterología · doi:10.22516/25007440.6 · Cited by 1
Substance Use Disorders: A Biopsychosocial Perspective
Duncan, P. M. (2020) · ODU Digital Commons (Old Dominion University) · Cited by 1
Alkoholabhängige: Erkennen und individuelles Behandeln nach der Typologie nach Lesch
Om, L., & Walter, H. (2013) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 1
LOSS OF CONTROL OVER SUBSTANCE USE
Minnaard, A. M. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/163 · Cited by 1
Pharmacological Approaches to the Treatment of Alcohol Dependence in the Young
Johnson, B. A. (2011) · Wiley eBooks · doi:10.1002/9781118785089.ch16
Self-citationvan Marle, H., LOONEN, A. J. M., & Roozen, H. G. (2012) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-8851-6_13
Alcohol and brain health: from mechanisms to interventions
Min, J., Kim, D., & Lee, C. U. (2010) · Journal of Korean Medical Association · doi:10.5124/jkma.2010.53.12.1115
Edgar Allan Poe's psychic daguerreotype
de Oliveira, J. R., & de Oliveira, M. F. (2015) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2014-1520
Alcohol Use and Depression: Public Health and Clinical Implications.
Kimberley Mental Health and Drug Service, B. W. 6., Balaratnasingam, S., & Janča, A. (2014) · International Journal of Clinical Psychiatry and Mental Health · doi:10.12970/2310-8231.2014.02.03.4
Effects of ondansetron on social behaviour in male mice
Pistovčáková, J., Krcek, L., & Šulcová, A. (2011)
Nguyen, R. H. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/4fvb-6v35
Genetic and environmental influences on alcohol behaviors: insight from the mouse transcriptome
Darlington, T. M. (2013) · CU Scholar (University of Colorado Boulder)
Skordal, A. J. (2012) · Montana State University ScholarWorks (Montana State University)
Integrative Approach to Alcohol Use Disorder
Wilkens, J., & Modir, S. J. (2018) · doi:10.1093/med/9780190275334.003.0004
Cannady, R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/2zjq-y805
Goldman, D. A., Landi, P., & Ducci, F. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-383834-6.00119-1
Psychiatric Disorders, Personality, and Developmental Factors
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.009
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.015
Use Disorders of Cocaine and Methamphetamine
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.014
Delile, J., & Couteron, J.-P. (2019) · Dunod eBooks · doi:10.3917/dunod.morel.2019.01.0135
Tranquilizers and Sedative Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.016
Alcohol use disorder pharmacotherapy options for postmenopausal females
Milic, J., Zekovic, J., Stankić, D., van Beeck, E. F., & Samardžić, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818000-6.00009-3
Faculty Opinions recommendation of Dihydromyricetin as a novel anti-alcohol intoxication medication.
Homanics, G. E., & Werner, D. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13836958.15275058
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.018
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.001
The Biopsychosocial Perspective and Research Methods for Investigation of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.002
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.010
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.004
Genetic Influence on Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.007
Brain Function and Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.006
Tobacco Use and Nicotine Addiction
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.012
Behavioral, Cognitive, and Social Factors Promoting SUD
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.008
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.005
Diagnosis of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.003
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.011
Treatment of Substance Use Disorders
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.017
(2011) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.9.1.foc72
Johnson, B. A., Alho, H., Addolorato, G., Lesch, O., Chick, J., Liu, L., Reich, J., Schuyler, V., & Rodd, Z. A. (2023) · Research Square · doi:10.21203/rs.3.rs-3093698/v1
Self-citationШушпанова, Т. В., Новожеева, Т. П., Bokhan, N. A., Новицкая, Л. Н., Удут, В. В., Smagina, M. I., Matveenko, A. V., Meleshko, M., Коломиец, Н. Э., Garganeeva, N. P., et al. (2023) · Pharmaceutical Chemistry Journal · doi:10.1007/s11094-023-02981-3
Involvement of FKBP5, but not of stress, in alcohol memory reconsolidationPreprint
Rahamim, N., Aronovici, C., Liran, M., Goltseker, K., Levin-Greenwald, M., Heymann, T., Hausch, F., & Barak, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.12.570934
Tratamento da dependência de álcool: diretrizes
de Psiquiatria, A. B., ABEAD, A. B. D. E. D. Á. E. O. D. , Marques, A. C. P. R., Ribeiro, M., Laranjeira, R., Zaleski, M., Gigliotti, A. D. P., & Salgado, C. A. I. (2011) · Debates em Psiquiatria · doi:10.25118/2763-9037.2011.v1.864
Chapter 17. Addiction Treatment and Harm Reduction
Sullivan, M. A., Marzani-Nissen, G., Lewis, C. E., Williams, A. R., LEVIN, F. R., Labins, Z., Patkar, A. A., & Aoun, E. G. (2020) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9780873182591.lg17
Varango, C., Varango, A., & Cella, M. (2025) · MISSION · doi:10.3280/mis69-2025oa19926
Unveiling the Notable Consequences in the Management of Anxiety Disorder
Gupta, V., & Srivastava, N. (2026) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v16i3.7631
Synthèses d’inhibiteurs de HDAC et leurs tests biologiques (Cytotoxicité, HDAC inhibition)
Ozdarska, K. (2020) · theses.fr (ABES) · doi:10.70675/9f872011z7544z4b35z8e5ezcf4812094c2e
Chapter 5. Alcohol Use and Use Disorder Among Older Adults
Gopalakrishna, G., Joshi, P., & Patel, N. (2024) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9798894551968.lg05
Fontenelle, L. F., Oostermeijer, S., Harrison, B. J., Pantelis, C., & Yücel, M. (2011) · Drugs · doi:10.2165/11591790-000000000-00000 · Cited by 234
“These drugs could be tested in patients showing OCD with co-morbid ICD/SUD,([9,10]) in individuals with treatment-refractory OCD([78]) or patients with a combination of these features.([10-79]) Alternatively, our model also suggests that some patients with ICD/SUD with compulsive features could respond to anti-OCD str…”
Background
Metadata
- Authors
- Johnson, B. A.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Johnson, Bankole A.
- ORCID
- Johnson, Bankole A.
- Venue
- American Journal of Psychiatry
- Published
- 2010-06-01
- Volume
- 167
- Issue
- 6
- Pages
- 630-639
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC2939449
- OpenAlex
- W2142440641
- Cited by
- 151
- References
- 72
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2021: 2 · 2020: 23 · 2019: 11 · 2018: 3 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 31
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA010522, R01AA013964, R01AA014628, U10AA011776, R01AA012964)
- National Center for Research Resources (M01RR000847, M01-RR 00847)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcoholism, pharmacological treatment of alcoholism, dopaminergic system, ondansetron, naltrexone, topiramate, baclofen, early-onset alcoholism, late-onset alcoholism, binge drinking, pharmacogenetics, brief behavioral intervention, abstinence
- MeSH terms
- Topiramate, Adult, Aged, Alcohol Deterrents, Alcoholism, Baclofen, Chronic Disease, Depressive Disorder, Female, Fructose, Humans, Hypothalamo-Hypophyseal System, Limbic System, Male, Naltrexone, Pituitary-Adrenal System, Ondansetron, Prefrontal Cortex, Receptors, Dopamine D2, Receptors, GABA, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
