The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Medication Treatment of Different Types of Alcoholism
Open accessAbstract
Alcoholism remains a serious cause of morbidity and mortality despite progress through neurobiological research in identifying new pharmacological strategies for its treatment. Drugs that affect neural pathways that modulate the activity of the cortico-mesolimbic dopamine system have been shown to alter drinking behavior, presumably because this dopaminergic system is closely associated with rewarding behavior. Ondansetron, naltrexone, topiramate, and baclofen are examples. Subtyping alcoholism in adults into an early-onset type, with chronic symptoms and a strong biological predisposition to the disease, and a late-onset type, typically brought on by psychosocial triggers and associated with mood symptoms, may help in the selection of optimal therapy. Emerging adults with binge drinking patterns also might be aided by selective treatments. Although preliminary work on the pharmacogenetics of alcoholism and its treatment has been promising, the assignment to treatment still depends on clinical assessment. Brief behavioral interventions that encourage the patient to set goals for a reduction in heavy drinking or abstinence also are part of optimal therapy.
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“To prevent the first drink, however, the psychological or cognitive threat is thought to be dominant and active and thus dissuade use [5], [6], [7].”
From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [7]
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“Alcohol dependence often follows a chronic, relapsing course (2) similar to other medical disorders, such as diabetes.”
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Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930
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“Those who drink severely or binge drink between the ages of 18 and 24 are more likely to progress to alcohol abuse or dependence diagnoses (29, 30).”
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Research works printed but not linked: 10
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- National Institute on Alcohol Abuse and Alcoholism: Helping Patients Who Drink Too Much: A Clinician's Guide: Updated 2005 Edition (NIH Publication No. 07–3769). Bethesda, Md, US Department of Health and Human Services, 2005
- Ait-Daoud N , Johnson BA : Medications for the treatment of alcoholism, in Handbook of Clinical Alcoholism Treatment. Edited by , Johnson BA , Ruiz P , Galanter M . Baltimore, Lippincott Williams & Wilkins, 2003, pp 119–130
Cited by
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EASL Clinical Practical Guidelines: Management of Alcoholic Liver Disease
European Association for the Study of the Liver (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.004 · Cited by 720
“The 5-HT3 antagonist ondansetron has been shown to reduce drinking, but this effect was limited to ‘early onset’ alcoholics [59].”
BackgroundConnor, J. P., Haber, P. S., & Hall, W. D. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00122-1 · Cited by 389
Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis
Skinner, M. D., Lahmek, P., Pham, H., & Aubin, H.-J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087366 · Cited by 347
“Its mechanism of action for maintaining alcohol abstinence is thought to be primarily psychological [4,5,6,7] and based on a highly disagreeable pharmacological effect if alcohol is consumed.”
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“Finally, the 5HT3 antagonist, ondansetron, has shown promise, particularly in early onset alcoholism (Johnson, 2010).”
BackgroundLeclercq, S., Cani, P. D., Neyrinck, A. M., Stärkel, P., Jamar, F., Mikolajczak, M., Delzenne, N. M., & de Timary, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.04.001 · Cited by 310
“Indeed current pharmacological approaches of alcohol-dependence that only target brain neurotransmitters have proved so far to be modestly efficient (Johnson, 2010), eventually because they fail to take into account of intestinal permeability and inflammation as a driving force for the…”
Metadata
- Authors
- Johnson, B. A.
- Affiliations
- University of Virginia (US)
- Corresponding author
- Johnson, Bankole A.
- ORCID
- Johnson, Bankole A.
- Venue
- American Journal of Psychiatry
- Published
- 2010-06-01
- Volume
- 167
- Issue
- 6
- Pages
- 630-639
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC2939449
- OpenAlex
- W2142440641
- Cited by
- 151
- References
- 72
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2021: 2 · 2020: 23 · 2019: 11 · 2018: 3 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 31
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA010522, R01AA013964, R01AA014628, U10AA011776, R01AA012964)
- National Center for Research Resources (M01RR000847, M01-RR 00847)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcoholism, pharmacological treatment of alcoholism, dopaminergic system, ondansetron, naltrexone, topiramate, baclofen, early-onset alcoholism, late-onset alcoholism, binge drinking, pharmacogenetics, brief behavioral intervention, abstinence
- MeSH terms
- Topiramate, Adult, Aged, Alcohol Deterrents, Alcoholism, Baclofen, Chronic Disease, Depressive Disorder, Female, Fructose, Humans, Hypothalamo-Hypophyseal System, Limbic System, Male, Naltrexone, Pituitary-Adrenal System, Ondansetron, Prefrontal Cortex, Receptors, Dopamine D2, Receptors, GABA, Young Adult
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