Cited by 310Parkinson's Disease Mechanisms and TreatmentsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

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Cognitive-Behavioral Therapy for Depression in Parkinson's Disease: A Randomized, Controlled Trial

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Dobkin, Roseanne D., Menza, Matthew, Allen, Lesley A., Gara, Michael A., Mark, Margery H., Tiu, Jade, Bienfait, Karina L., Friedman, Jill·2011·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2011.10111669PMC PMC3186855

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Abstract

OBJECTIVE: Despite the negative effects of depression in Parkinson's disease, there is currently no evidence-based standard of care. The purpose of this study was to examine the efficacy of individually administered cognitive-behavioral therapy (CBT), relative to clinical monitoring (with no new treatment), for depression in this medical population. METHOD: Eighty depressed (based on DSM-IV criteria) patients with Parkinson's disease participated in a randomized, controlled trial of CBT relative to clinical monitoring (1:1 ratio) in an academic medical center from April 2007 to July 2010. All patients continued to maintain stable medication regimens under the care of their personal physicians. The 17-item Hamilton Depression Rating Scale (HAM-D) total score was the primary outcome. CBT was modified to meet the unique needs of the Parkinson's disease population and provided for 10 weeks. Assessments were completed by blind raters at baseline and 5 (midpoint), 10 (end of treatment), and 14 weeks (follow-up evaluation) postrandomization. RESULTS: The CBT group reported greater reductions in depression (change in HAM-D score) than the clinical monitoring group. At week 10, the mean HAM-D score change was 7.35 for CBT relative to 0.05 for clinical monitoring. CBT was also superior to clinical monitoring on several secondary outcomes (i.e., Beck Depression Inventory scores, anxiety, quality of life, coping, Parkinson's disease symptom ratings). There were more treatment responders in the CBT group than the clinical monitoring group (56% versus 8%, respectively). CONCLUSIONS: CBT may be a viable approach for the treatment of depression in Parkinson's disease. Further research is needed to replicate and extend these findings.

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Authors: Dobkin, R. D., Menza, M., Allen, L. A., Gara, M. A., Mark, M. H., Tiu, J., Bienfait, K. L., & Friedman, J.
Affiliations: University of Medicine and Dentistry of New Jersey (US)
ORCID: Dobkin, Roseanne D.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2011-10
Volume: 168
Issue: 10
Pages: 1066-1074
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2011.10111669
PMC: PMC3186855
OpenAlex: W1969355958
Cited by: 310
References: 49
Citations by year: 2026: 16 · 2025: 15 · 2024: 18 · 2023: 17 · 2022: 25 · 2021: 17 · 2020: 18 · 2019: 21 · 2018: 15 · 2017: 24 · 2016: 23 · 2015: 29 · 2014: 24 · 2013: 30 · 2012: 12
FWCI: 14.60
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K23NS052155)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: cognitive behavioral therapy, depression, Parkinson's disease, treatment efficacy, patient monitoring, Hamilton Depression Rating Scale, anxiety, quality of life, coping
MeSH terms: Adult, Aged, Aged, 80 and over, Depressive Disorder, Female, Humans, Male, Middle Aged, Parkinson Disease, Cognitive Behavioral Therapy, Single-Blind Method, Treatment Outcome

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Cognitive-Behavioral Therapy for Depression in Parkinson's Disease: A Randomized, Controlled Trial

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