The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Long-Term Follow-Up of the TIPS Early Detection in Psychosis Study: Effects on 10-Year Outcome
Abstract
OBJECTIVE: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis. METHOD: The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery. RESULTS: A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group. CONCLUSIONS: Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.
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Cites
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Cited by
Galletly, C., Castle, D., Dark, F., Humberstone, V., Jablensky, A., Killackey, E., Kulkarni, J., McGorry, P., Nielssen, O., & Tran, N. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416641195 · Cited by 877
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Penttilä, M., Jääskeläinen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.127753 · Cited by 716
The Lancet Psychiatry Commission on youth mental health
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Hunt, G. E., Large, M. M., Cleary, M., Lai, H. M. X., & Saunders, J. B. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.07.011 · Cited by 482
Metadata
- Authors
- Hegelstad, W. T. V., Larsen, T. K., Auestad, B., Evensen, J., Haahr, U., Joa, I., Johannesen, J. O., Langeveld, J., Melle, I., Opjordsmoen, S., Rossberg, J. I., Rund, B. R., Simonsen, E., Sundet, K., Vaglum, P., Friis, S., & McGlashan, T.
- Venue
- American Journal of Psychiatry
- Published
- 2012-04
- Volume
- 169
- Issue
- 4
- Pages
- 374-380
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2160738158
- Cited by
- 309
- References
- 33
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hegelstad, W. T. V., Larsen, T. K., Auestad, B., Evensen, J., Haahr, U., Joa, I., Johannesen, J. O., Langeveld, J., Melle, I., Opjordsmoen, S., Rossberg, J. I., Rund, B. R., Simonsen, E., Sundet, K., Vaglum, P., Friis, S., & McGlashan, T. (2012). Long-Term Follow-Up of the TIPS Early Detection in Psychosis Study: Effects on 10-Year Outcome. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.2011.11030459
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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