The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Open accessAbstract
OBJECTIVE The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) and to identify the neural correlates of these behaviors. METHOD Data were collected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteria (high-risk negative), and 41 were low-risk infants. All infants underwent an eye-tracking task at a mean age of 7 months and a clinical assessment at a mean age of 25 months. Diffusion-weighted imaging data were acquired for 84 of the infants at 7 months. Primary outcome measures included average saccadic reaction time in a visually guided saccade procedure and radial diffusivity (an index of white matter organization) in fiber tracts that included corticospinal pathways and the splenium and genu of the corpus callosum. RESULTS Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants. Visual orienting latencies were uniquely associated with the microstructural organization of the splenium of the corpus callosum in low-risk infants, but this association was not apparent in infants later classified as having an ASD. CONCLUSIONS Flexibly and efficiently orienting to salient information in the environment is critical for subsequent cognitive and social-cognitive development. Atypical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.
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“Our findings are consistent with reports of subtle motor differences at 6–7 months with respect to head control [13], lower activity level [52], and saccadic reaction times [9] among infants who go on to develop ASD.”
From Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life (2015) · cites this paper as [9]
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Cites
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“Clinical diagnosis was corroborated in the proband of high-risk infants with the Autism Diagnostic Interview–Revised (18).”
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Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371
Early brain development in infants at high risk for autism spectrum disorder
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Background
Metadata
- Authors
- Elison, J. T., Paterson, S. J., Wolff, J. J., Reznick, J. S., Sasson, N. J., Gu, H., Botteron, K. N., Dager, S. R., Estes, A. M., Evans, A. C., Gerig, G., Hazlett, H. C., Schultz, R. T., Styner, M., Zwaigenbaum, L., Piven, J., & for the IBIS Network
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2013-08
- Volume
- 170
- Issue
- 8
- Pages
- 899-908
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3863364
- OpenAlex
- W2133015692
- Cited by
- 277
- References
- 46
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 21 · 2020: 53 · 2019: 26 · 2018: 15 · 2017: 21 · 2016: 30 · 2015: 23 · 2014: 25 · 2013: 11
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Autism Speaks
- Pfizer
- National Institutes of Health (HD 03110, EB005149)
- Intellectual and Developmental Disabilities Research Center (T32 HD40127, P30 HD03110)
- National Institute of Mental Health (R01MH091645)
- National Institute of Biomedical Imaging and Bioengineering (U54EB005149)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-40127, HD055741-S1, P30-HD03110, P30HD003110, T32HD007376, T32HD040127, R01HD055741)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, visual orienting, white matter microstructure, radial diffusivity, splenium of corpus callosum, saccade latency, oculomotor development, familial risk, corticospinal tract, eye tracking, diffusion-weighted imaging, infant development
- MeSH terms
- Attention, Brain, Brain Mapping, Cerebral Cortex, Child Development Disorders, Pervasive, Cognition Disorders, Corpus Callosum, Female, Follow-Up Studies, Humans, Image Interpretation, Computer-Assisted, Infant, Male, Nerve Fibers, Neurons, Orientation, Pyramidal Tracts, Reaction Time, Reference Values, Reticular Formation, Saccades, Superior Colliculi, Visual Pathways, Genetic Predisposition to Disease, Diffusion Magnetic Resonance Imaging, Emotional Intelligence, Leukoencephalopathies
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