The DOI matches its Crossref record; 230 of the 230 references it cites were found in a registry or an index.
The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders
Open accessAbstract
A large body of evidence has demonstrated that exposure to childhood maltreatment at any stage of development can have long-lasting consequences. It is associated with a marked increase in risk for psychiatric and medical disorders. This review summarizes the literature investigating the effects of childhood maltreatment on disease vulnerability for mood disorders, specifically summarizing cross-sectional and more recent longitudinal studies demonstrating that childhood maltreatment is more prevalent and is associated with increased risk for first mood episode, episode recurrence, greater comorbidities, and increased risk for suicidal ideation and attempts in individuals with mood disorders. It summarizes the persistent alterations associated with childhood maltreatment, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course. The authors discuss several candidate genes and environmental factors (for example, substance use) that may alter disease vulnerability and illness course and neurobiological associations that may mediate these relationships following childhood maltreatment. Studies provide insight into modifiable mechanisms and provide direction to improve both treatment and prevention strategies.
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“not all individuals who experience life stress develop MDD and/or a physical disease153,154.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [154]
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“Early life stress (ELS) due to childhood abuse and/or neglect has been linked to increased risk of psychiatric illness onset and recurrence, increased disease severity and poor treatment response (pharmacotherapy and psychotherapy) (148, 149).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [149]
In the citing paper
“Recent research on childhood abuse and neglect, for instance, emphasises the lasting effects on the risks for depression not only in childhood and adolescence, but also later in life and in subsequent generations. 11”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [11]
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“Various forms of abuse (Lippard and Nemeroff, 2020) and other common histories for people with mental health problems (Van der Kolk, 2015) indicate that either they did not experience feeling a sense of security or safeness and “loving” empathic engagement with developmental needs being met, and/or as they move throug…”
BackgroundTeicher, M. H., Gordon, J. B., & Nemeroff, C. B. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01367-9 · Cited by 325
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Metadata
- Authors
- Lippard, E. T. C., & Nemeroff, C. B.
- Affiliations
- The University of Texas at Austin (US)
- Venue
- American Journal of Psychiatry
- Published
- 2020-01-01
- Volume
- 177
- Issue
- 1
- Pages
- 20-36
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC6939135
- OpenAlex
- W2973818823
- Cited by
- 527
- References
- 230
- Citations by year
- 2026: 60 · 2025: 88 · 2024: 91 · 2023: 96 · 2022: 104 · 2021: 58 · 2020: 25
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Brain and Behavior Research Foundation
- American Foundation for Suicide Prevention
- American Psychiatric Publishing
- Celgene
- Sunovion
- OPKO Health
- National Institutes of Health (AA024933)
- Department of Mechanical Engineering, University of Texas at Austin
- Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin
- Dell Medical School, University of Texas at Austin
- Laureate Institute for Brain Research, University of Tulsa
- National Institute on Alcohol Abuse and Alcoholism (K01AA027573, R01AA024933)
- National Institute of Mental Health (R01MH117293)
- Janssen Research and Development
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- child abuse, mood disorders, bipolar disorder, depression, disease susceptibility, treatment response, suicidal ideation, suicide attempts, episode recurrence, comorbidities, hypothalamic-pituitary-adrenal axis, inflammatory cytokines, candidate genes, substance use, neurobiology of depression, prevention
- MeSH terms
- Child, Child Abuse, Disease Susceptibility, Humans, Risk Factors, Comorbidity, Mood Disorders
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