Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?: Where the Rubber Meets the Road
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inflammatory markers are elevated not only in a subgroup of patients with depression but also in patients with other neuropsychiatric disorders including anxiety disorders and schizophrenia.
“inflammatory markers are elevated not only in a subgroup of patients with depression30,31 but also in patients with other neuropsychiatric disorders including anxiety disorders and schizophrenia32,33.”
From The role of inflammation in depression: from evolutionary imperative to modern treatment target (2016) · cites this paper as [31]
The Inflammation section (page unavailable) says that only subgroups of patients with any given psychiatric disease have increased inflammatory markers and discusses depression and schizophrenia. The Trust But Verify section says these markers are elevated across a variety of psychiatric disorders. The paper discusses anxiety as a symptom of inflammation, but does not specifically report elevated markers in patients diagnosed with anxiety disorders. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works
Self-citationImmune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
Haroon, E., Raison, C. L., & Miller, A. H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.205 · Cited by 1,000 · see citing works
Self-citationKöhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works
Uher, R., Tansey, K. E., Dew, T., Maier, W., Mors, O., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010094 · Cited by 418 · see citing works
National Institute of Mental Health Clinical Trials
Insel, T. R., & Gogtay, N. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.426 · Cited by 170 · see citing works
Manabe, T., Togashi, H., Uchida, N., Suzuki, S. C., Hayakawa, Y., Yamamoto, M., Yoda, H., Miyakawa, T., Takeichi, M., & Chisaka, O. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0849 · Cited by 154 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The role of inflammation in depression: from evolutionary imperative to modern treatment target
Miller, A. H., & Raison, C. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.5 · Cited by 3,942 · see citing works
Self-citationVagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00044 · Cited by 1,189 · see citing works
Inflammation: Depression Fans the Flames and Feasts on the Heat
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020152 · Cited by 844 · see citing works
An active inference theory of allostasis and interoception in depression
Barrett, L. F., Quigley, K. S., & Hamilton, P. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0011 · Cited by 554 · see citing works
Kopschina Feltes, P., Doorduin, J., Klein, H. C., Juárez-Orozco, L. E., Dierckx, R. A., Moriguchi-Jeckel, C. M., & de Vries, E. F. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711708 · Cited by 279 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Self-citationMiller, A. H., & Raison, C. L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01887-y · Cited by 67 · see citing works
Self-citationInflamed brain: Targeting immune changes and inflammation for treatment of depression
Sakamoto, S., Zhu, X., Hasegawa, Y., Karma, S., Obayashi, M., Alway, E., & Kamiya, A. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13286 · Cited by 51 · see citing works
Godara, M., Silveira, S., Matthäus, H., Heim, C., Voelkle, M., Hecht, M., Binder, E. B., & Singer, T. (2021) · PLOS ONE · doi:10.1371/journal.pone.0256323 · Cited by 38 · see citing works
McFarland, D. C., Walsh, L. E., Saracino, R., Nelson, C. J., Breitbart, W., & Rosenfeld, B. (2021) · Palliative and Supportive Care · doi:10.1017/s1478951520001169 · Cited by 5 · see citing works
- Authors
- Miller, A. H., & Raison, C. L.
- Affiliations
- Emory University (US)
- University of Arizona (US)
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2015-06-01
- Volume
- 72
- Issue
- 6
- Pages
- 527
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC5542670
- OpenAlex
- W1997291002
- Cited by
- 101
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 8 · 2020: 14 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 7
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454, TL1TR000456)
- National Institute of Mental Health (R21MH077172, R03MH100273, R01MH087604)
- National Cancer Institute (P30CA138292)
- National Center for Research Resources (UL1RR025008)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- anti-inflammatory therapy, mental illness, inflammation, depression, bipolar disorder, schizophrenia, treatment efficacy
- MeSH terms
- Anti-Inflammatory Agents, Mental Disorders, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
