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Cited by 796Mental Health Treatment and AccessMedication Adherence and ComplianceTreatment of Major Depression

The DOI matches its Crossref record; 22 of the 24 references it cites were found in a registry or an index.

Stigma as a Barrier to Recovery: Perceived Stigma and Patient-Rated Severity of Illness as Predictors of Antidepressant Drug Adherence

Sirey, Jo Anne, Bruce, Martha L., Alexopoulos, George S., Perlick, Deborah A., Friedman, Steven J., Meyers, Barnett S.·2001·Psychiatric Services
DOI 10.1176/appi.ps.52.12.1615
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Abstract

OBJECTIVE: Major depression is undertreated despite the availability of effective treatments. Psychological barriers to treatment, such as perceived stigma and minimization of the need for care, may be important obstacles to adherence to the pharmacologic treatment of major depression. The authors examined the impact of barriers that were present at the initiation of antidepressant drug therapy on medication adherence in a mixed-age sample of outpatients with major depression. METHODS: A two-stage sampling design was used to identify adults with a diagnosis of major depressive disorder, as determined by the Structured Clinical Interview for Diagnosis, who sought mental health treatment at outpatient clinics. Additional instruments were administered to 134 newly admitted adults who had been taking a prescribed antidepressant medication for at least a week to assess perceived stigma, self-rated severity of illness, and views about treatment. The patients were reinterviewed three months later and were classified as adherent or nonadherent on the basis of self-reported estimates of the number and frequency of missed doses. RESULTS: Medication adherence was associated with lower perceived stigma, higher self-rated severity of illness, age over 60 years, and absence of personality pathology. No other characteristics of treatment or illness were significantly related to medication adherence. CONCLUSIONS: Perceived stigma associated with mental illness and individuals' views about the illness play an important role in adherence to treatment for depression. Clinicians' attention to psychological barriers early in treatment may improve medication adherence and ultimately affect the course of illness.

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Crossref · 10.1176/appi.ps.52.12.1615

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Metadata

Authors
Sirey, J. A., Bruce, M. L., Alexopoulos, G. S., Perlick, D. A., Friedman, S. J., & Meyers, B. S.
Affiliations
NewYork–Presbyterian Hospital (US)
ORCID
Venue
Psychiatric Services
Publisher
American Psychiatric Association Publishing
Published
2001-12
Volume
52
Issue
12
Pages
1615-1620
ISSN
  • 0022-1597 (ISSN-L)
  • 1075-2730
  • 1557-9700
DOI
10.1176/appi.ps.52.12.1615
OpenAlex
W2125103779
Cited by
796
References
24
Citations by year
2026: 12 · 2025: 16 · 2024: 16 · 2023: 49 · 2022: 21 · 2021: 28 · 2020: 38 · 2019: 23 · 2018: 26 · 2017: 70 · 2016: 45 · 2015: 37 · 2014: 38 · 2013: 51 · 2012: 43
FWCI
18.98
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Services (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r24mh053816-05)
  • National Institute of Mental Health (MH53816)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
perceived stigma, medication adherence, antidepressants, major depressive disorder, undertreatment of depression, personality pathology, age over 60, outpatients
MeSH terms
Adaptation, Psychological, Adult, Aged, Antidepressive Agents, Attitude to Health, Mental Disorders, Female, Humans, Male, Middle Aged, Patient Compliance, Stereotyping, Recovery of Function

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