Why Do Some Cancer Patients With Depression Desire an Early Death and Others Do Not?
Abstract
Major depression is a well-documented risk factor for suicide in cancer patients as well as in the general population. However, there are no data explaining why some cancer patients suffering from major depression have suicidal ideation, while others do not. The authors investigated the background differences among cancer patients suffering from major depression with and without suicidal ideation by analyzing the consultation data of patients referred to the psychiatry division. Among the 1,721 referred patients, 220 (12.8%) were diagnosed with major depression, and of these 113 (51.4%) had suicidal ideation. Logistic regression analysis indicated that poor physical functioning and severe depression were significant risk factors. These preliminary findings suggest that the severity of major depression and physical functioning are important indicators of suicidal ideation among cancer patients.
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The prevalence of suicidal ideation in this study was similar to that of an earlier work on cancer patients with major depression referred to a psychiatry service (51.4%).
“Our finding was similar to that of an earlier work on cancer patients with major depression referred to a psychiatry service, 51.4%.5”
From Prevalence and Correlates of Suicidal Ideation among Psycho-Oncology Outpatients (2024) · cites this paper as [5]
Cites
Desire for death in the terminally ill
Chochinov, H. M., Wilson, K. G., Enns, M. W., Mowchun, N., Lander, S., Levitt, M., & Clinch, J. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1185 · Cited by 742 · see citing works
Depression in Patients With Cancer
McDaniel, J. S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950140007002 · Cited by 541 · see citing works
FAWCETT, J. A., Scheftner, W. A., Clark, D., Hedeker, D., Gibbons, R. D., & Coryell, W. H. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.1.35 · Cited by 384 · see citing works
Koenig, H. G., George, L. K., Peterson, B. L., & Pieper, C. F. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.10.1376 · Cited by 335 · see citing works
Spiegel, D. (1996) · The British Journal of Psychiatry · doi:10.1192/s0007125000298486 · Cited by 304 · see citing works
Legalized Physician-Assisted Suicide in Oregon — The First Year's Experience
Chin, A. E., Hedberg, K., Higginson, G. K., & Fleming, D. W. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902183400724 · Cited by 282 · see citing works
Assessment and Treatment of Suicidal Patients
Hirschfeld, R. M. A., & Russell, J. M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709253371307 · Cited by 271 · see citing works
Depression in patients with cancer
Mermelstein, H. T., & Lesko, L. M. (1992) · Psycho-Oncology · doi:10.1002/pon.2960010404 · Cited by 265 · see citing works
Legalized Physician-Assisted Suicide in Oregon — The Second Year
Sullivan, A. D., Hedberg, K., & Fleming, D. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420822 · Cited by 239 · see citing works
Clinical Determinants of Suicidal Ideation and Behavior in Geriatric Depression
Alexopoulos, G. S., BRUCE, M. L., Hull, J. W., Sirey, J. A., & Kakuma, T. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1048 · Cited by 213 · see citing works
Kissane, D. W., Street, A. F., & Nitschke, P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)05406-3 · Cited by 206 · see citing works
Absence of major depressive disorder in female cancer patients.
Lansky, S. B., List, M. A., Herrmann, C., Ets-Hokin, E. G., DasGupta, T. K., Wilbanks, G. D., & Hendrickson, F. R. (1985) · Journal of Clinical Oncology · doi:10.1200/jco.1985.3.11.1553 · Cited by 148 · see citing works
Psychiatric disorder in patients with advanced breast cancer: Prevalence and associated factors
Ramirez, A. J., Pinder, K. L., Black, M. E., Richards, M., Gregory, W. M., & Rubens, R. D. (1993) · European Journal of Cancer · doi:10.1016/s0959-8049(05)80144-3 · Cited by 112 · see citing works
Features associated with suicide attempts in recurrent major depression
Bulik, C. M., Carpenter, L. L., Kupfer, D. J., & Frank, E. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90114-n · Cited by 105 · see citing works
Depression and suicide in patients with cancer
Massie, M. J., Gagnon, P. R., & Holland, J. C. (1994) · Journal of Pain and Symptom Management · doi:10.1016/0885-3924(94)90192-9 · Cited by 102 · see citing works
Predictors of patients' mental adjustment to cancer: patient characteristics and social support
Akechi, T., Okamura, H., Yamawaki, S., & Uchitomi, Y. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.396 · Cited by 86 · see citing works
Self-citationSuicidal thoughts in cancer patients: Clinical experience in psycho‐oncology
Akechi, T., Kugaya, A., Okamura, H., Nakano, T., Okuyama, T., Mikami, I., Shima, Y., Yamawaki, S., & Uchitomi, Y. (1999) · Psychiatry and Clinical Neurosciences · doi:10.1046/j.1440-1819.1999.00607.x · Cited by 53 · see citing works
Self-citationRoy, A. (1983) · Comprehensive Psychiatry · doi:10.1016/0010-440x(83)90040-8 · Cited by 45 · see citing works
Is introversion a risk factor for suicidal behaviour in depression?
Roy, A. (1998) · Psychological Medicine · doi:10.1017/s0033291798007028 · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Krebber, A. M. H., Buffart, L. M., Kleijn, G., Riepma, I. C., de Bree, R., Leemans, C. R., Becker, A., Brug, J., van Straten, A., Cuijpers, P., et al. (2014) · Psycho-Oncology · doi:10.1002/pon.3409 · Cited by 908 · see citing works
Effect of spiritual well-being on end-of-life despair in terminally-ill cancer patients
McClain, C. S., Rosenfeld, B., & Breitbart, W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13310-7 · Cited by 812 · see citing works
Psychological and behavioral approaches to cancer pain management
Syrjala, K. L., Jensen, M. P., Mendoza, M. E., Yi, J. C., Fisher, H. M., & Keefe, F. J. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.4825 · Cited by 344 · see citing works
Suicide Risk in Cancer Patients From 1960 to 1999
Hem, E., Loge, J. H., Haldorsen, T., & Ekeberg, Ø. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.052 · Cited by 252 · see citing works
The risk of suicide in cancer patients: a review of the literature
Robson, A., Scrutton, F., Wilkinson, L., & MacLeod, F. (2010) · Psycho-Oncology · doi:10.1002/pon.1717 · Cited by 199 · see citing works
Better Off Dead: Suicidal Thoughts in Cancer Patients
Walker, J., Waters, R. A., Murray, G., Swanson, H., Hibberd, C. J., Rush, R. W., Storey, D. J., Strong, V. A., Fallon, M. T., Wall, L. R., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.8844 · Cited by 195 · see citing works
Rodríguez‐Prat, A., Balaguer, A., Booth, A., & Monforte‐Royo, C. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-016659 · Cited by 183 · see citing works
Factors associated with the wish to hasten death: a study of patients with terminal illness
Kelly, B. J., Burnett, P. C., Pelusi, D., Badger, S. J., Varghese, F. T. N., & Robertson, M. (2002) · Psychological Medicine · doi:10.1017/s0033291702006827 · Cited by 148 · see citing works
Ross, S., Agin-Liebes, G., Lo, S., Zeifman, R. J., Ghazal, L., Benville, J., Franco Corso, S., Bjerre Real, C., Guss, J., Bossis, A., et al. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00020 · Cited by 139 · see citing works
The wish to hasten death: a review of clinical studies
Monforte‐Royo, C., Villavicencio‐Chávez, C., Tomás‐Sábado, J., & Balaguer, A. (2010) · Psycho-Oncology · doi:10.1002/pon.1839 · Cited by 116 · see citing works
Are Patients with Parkinson's Disease Suicidal?
Myslobodsky, M. S., Lalonde, F. M., & HICKS, L. H. (2001) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870101400304 · Cited by 114 · see citing works
Kolva, E., Hoffecker, L., & Cox-Martin, E. (2020) · Palliative and Supportive Care · doi:10.1017/s1478951519000610 · Cited by 108 · see citing works
Clinical Correlates of Suicidal Thoughts in Patients With Advanced Cancer
Spencer, R. J., Ray, A., Pirl, W. F., & Prigerson, H. G. (2011) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318233171a · Cited by 102 · see citing works
Terminally ill cancer patients' wish to hasten death
Kelly, B. J., Burnett, P. C., Pelusi, D., Badger, S. J., Varghese, F. T. N., & Robertson, M. S. (2002) · Palliative Medicine · doi:10.1191/0269216302pm538oa · Cited by 98 · see citing works
Suicide and cancer: Where do we go from here?
Spoletini, I., Gianni, W., Caltagirone, C., Madaio, R., Repetto, L., & Spalletta, G. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.05.005 · Cited by 157 · see citing works
Depression and end-of-life care for patients with cancer
Rosenstein, D. L. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/drosenstein · Cited by 92 · see citing works
Suicide Rates and Risk Factors among Korean Cancer Patients, 1993-2005
Ahn, E., Shin, D. W., Cho, S., Park, S., Won, Y., & Yun, Y. H. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0261 · Cited by 89 · see citing works
Suicide in cancer patients in South East England from 1996 to 2005: a population-based study
Robinson, D., Renshaw, C., Okello, C., Møller, H., & Davies, E. A. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605110 · Cited by 75 · see citing works
Clinical Factors Associated with Suicidality in Cancer Patients
Akechi, T. (2002) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyf106 · Cited by 54 · see citing works
Self-citationKelly, B. J., Burnett, P. C., Pelusi, D., Badger, S. J., Varghese, F. T. N., & Robertson, M. (2004) · Psychosomatics · doi:10.1176/appi.psy.45.4.311 · Cited by 41 · see citing works
Risk of suicide within 1 year of cancer diagnosis
Wang, S., Chang, J., Weng, S., Yeh, M., & Lee, C. (2017) · International Journal of Cancer · doi:10.1002/ijc.31224 · Cited by 38 · see citing works
Kutner, J. S., & Kilbourn, K. M. (2009) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2009.07.004 · Cited by 36 · see citing works
Suicide ideation in stomach cancer survivors and possible risk factors
Choi, Y.-N., Kim, Y., Yun, Y. H., Kim, S. H., Bae, J.-M., Kim, Y., Ryu, K. W., Lee, J. H., Noh, J. H., & Sohn, T.-S. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1975-4 · Cited by 35 · see citing works
Cohen, L. M., & Germain, M. J. (2005) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2005.18201.x · Cited by 32 · see citing works
Ito, T., Shimizu, K., Ichida, Y., Ishibashi, Y., Akizuki, N., Ogawa, A., Fujimori, M., Kaneko, N., Ueda, I., Nakayama, K., et al. (2011) · Psycho-Oncology · doi:10.1002/pon.1945 · Cited by 31 · see citing works
Self-citationYıldırım, Y., Sertöz, Ö. Ö., Uyar, M., Fadıloğlu, Ç., & Uslu, R. (2009) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2009.01.001 · Cited by 31 · see citing works
Knops, K., Srinivasan, M., & Meyers, F. J. (2005) · Palliative & Supportive Care · doi:10.1017/s1478951505050455 · Cited by 27 · see citing works
Georges, J., Onwuteaka-Philipsen, B. D., van der Heide, A., van der Wal, G., & van der Maas, P. J. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.06.013 · Cited by 23 · see citing works
The Desire for Death in the Setting of Terminal Illness
Maytal, G. (2006) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v08n0507 · Cited by 22 · see citing works
Parpa, E., Tsilika, E., Galanos, A., Nikoloudi, M., & Mystakidou, K. (2019) · Supportive Care in Cancer · doi:10.1007/s00520-019-04715-2 · Cited by 22 · see citing works
Sex- and age-specific trends in mortality from suicide and undetermined death in Germany 1991–2002
Baumert, J. J., Erazo, N., & Ladwig, K. (2005) · BMC Public Health · doi:10.1186/1471-2458-5-61 · Cited by 22 · see citing works
Are suicide rates higher in the cancer population? An investigation using forensic autopsy data
de la Grandmaison, G. L., Watier, L., Cavard, S., & Charlier, P. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.10.025 · Cited by 19 · see citing works
Depressive Störungen bei körperlich Kranken
Arolt, V., & Rothermundt, M. (2003) · Der Nervenarzt · doi:10.1007/s00115-003-1629-8 · Cited by 40 · see citing works
Taur, F., Chai, S.-K. D., Chen, M., Hou, J., Lin, S., & Tsai, S. (2011) · Journal of Clinical Nursing · doi:10.1111/j.1365-2702.2011.03808.x · Cited by 17 · see citing works
Attending to Psychologic Symptoms and Palliative Care
Agrawal, M. K., & Emanuel, E. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.624 · Cited by 16 · see citing works
END-OF-LIFE CARE AND EUTHANASIA: ATTITUDES OF MEDICAL STUDENTS AND DYING CANCER PATIENTS
Karlsson, M. (2011) · Figshare · Cited by 15 · see citing works
Patients with cancer: cognitions and emotions coming from diagnosis
Simeão, S. D. S. S., de Aquino, T. A. A., & dos Santos, R. M. (2008) · Revista Brasileira de Terapias Cognitivas · doi:10.5935/1808-5687.20080016 · Cited by 13 · see citing works
Walker, J., Magill, N., Rosenstein, D. L., Frost, C. D., & Sharpe, M. (2021) · Journal of the Academy of Consultation-Liaison Psychiatry · doi:10.1016/j.jaclp.2021.09.003 · Cited by 12 · see citing works
Physician-assisted suicide: Saying what we mean and meaning what we say
Vamos, M. J. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867411432069 · Cited by 11 · see citing works
Gentile, G., Tambuzzi, S., Calati, R., & Zoja, R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020829 · Cited by 10 · see citing works
Universitat Internacional de Catalunya
Barba, E. L. (2017) · Dialnet (Universidad de la Rioja) · Cited by 10 · see citing works
Assessing the Risk for Suicide in Patients With Cancer
Aiello, L. B. (2010) · Clinical journal of oncology nursing · doi:10.1188/10.cjon.687-691 · Cited by 9 · see citing works
Psycho-oncology in Korea: past, present and future
Lee, H. J., Lee, K.-M., Jung, D., Shim, E.-J., Hahm, B., & Kim, J. (2017) · BioPsychoSocial Medicine · doi:10.1186/s13030-017-0097-5 · Cited by 9 · see citing works
Depression bei körperlichen Erkrankungen
Arolt, V., & Rothermundt, M. (2004) · Steinkopff eBooks · doi:10.1007/978-3-662-12845-9_19 · Cited by 9 · see citing works
Psychotherapie in der palliativen Versorgung
Mehnert, A. (2015) · PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie · doi:10.1055/s-0035-1552758 · Cited by 8 · see citing works
Suicide prevention among patients with cancer
Akechi, T. (2019) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2019.09.004 · Cited by 7 · see citing works
Self-citationWoods, A. B. (2003) · Journal of Hospice and Palliative Nursing · doi:10.1097/00129191-200310000-00012 · Cited by 6 · see citing works
Uchitomi, Y., Kugaya, A., Akechi, T., Nakano, T., Inagaki, M., Matsuoka, Y., Kagaya, A., & Yamawaki, S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01420-8 · Cited by 6 · see citing works
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Park, C. H. K., Kim, H., Kim, Y., Park, S. Y., & Joo, Y. H. (2024) · Yonsei Medical Journal · doi:10.3349/ymj.2023.0484 · Cited by 3 · see citing works
Depression in Medical Patients
Arolt, V., & Rothermundt, M. (2004) · KARGER eBooks · doi:10.1159/000079763 · Cited by 3 · see citing works
Clinical psychology in palliative care
Mehnert, A. (2015) · doi:10.1093/med/9780199656097.003.0413 · Cited by 3 · see citing works
Psycho-oncology and Palliative Care: Two Concepts That Fit into Comprehensive Cancer Care
Weber, D., Gründel, M., & Mehnert, A. (2015) · Springer eBooks · doi:10.1007/978-3-662-46202-7_14 · Cited by 2 · see citing works
Akechi, T., Okamura, H., Nishiwaki, Y., & Uchitomi, Y. (2003) · Cancer · doi:10.1002/cncr.11455 · Cited by 1 · see citing works
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Kelly, C., & Jorm, A. F. (2013) · Trends in Urology & Men s Health · doi:10.1002/tre.318
Depression and Reasons for Living Among AIDS Patients
Marquart, A. L. (2009) · OhioLink ETD Center (Ohio Library and Information Network)
Factors associated with the wish to hasten death: a study of patients with terminal illness
Urnett, P. B., Elusi, D. P., Adger, S. B., Arghese, F. V., Obertson, M. R., & Olivet, M. (2003)
Ética das pesquisas envolvendo pessoas com transtornos mentais maiores
Bonella, A. E., de Almeida, G. F., & Almada, L. F. (2021) · ethic - An international Journal for Moral Phylosophy · doi:10.5007/1677-2954.2021.e80051
Depression among cancer patients: A major epidemic
Debnath, B., Sarkar, A., & Sarkar, A. (2022) · International journal of advanced psychiatric nursing · doi:10.33545/26641348.2022.v4.i2a.88
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de Carvalho, L. F. F., & Miasso, A. I. (2026) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2024-0573pt
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- Authors
- Akechi, T., Okamura, H., Yamawaki, S., & Uchitomi, Y.
- Affiliations
- Hiroshima University (JP)
- Corresponding author
- Akechi, Tatsuo
- Venue
- Psychosomatics
- Publisher
- Elsevier BV
- Published
- 2001-03
- Volume
- 42
- Issue
- 2
- Pages
- 141-145
- ISSN
- 0033-3182 (ISSN-L)
- OpenAlex
- W2095225953
- Cited by
- 61
- References
- 19
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 2 · 2021: 3 · 2019: 3 · 2017: 4 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychosomatics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
- Keywords
- cancer patients, major depressive disorder, suicidal ideation, suicide risk factors, physical function, depression severity, psychiatric referral
- MeSH terms
- Suicide Prevention, Adaptation, Psychological, Attitude to Death, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Middle Aged, Neoplasms, Psychiatric Status Rating Scales, Severity of Illness Index, Social Adjustment, Prevalence
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