The neuropsychiatry of adult-onset adrenoleukodystrophy
Abstract
Adrenoleukodystrophy is an inherited X-linked peroxisomal disorder that preferentially affects the adrenal cortex, testes, and brain and may occur at almost any age. Psychiatric symptomatology is present in many of the adult-onset cases reported in the literature and may be one of the earliest manifestations of the disease. The majority of patients with psychiatric disturbances have signs and symptoms typical of mania. Psychosis and cognitive impairment may also be prominent. Metabolic diseases such as adrenoleukodystrophy are probably underrecognized as a cause of psychiatric illness. Increased awareness of these disorders will lead to accurate diagnosis, appropriate treatment selection, and genetic counseling.
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Cognitive decline and psychiatric manifestations in cALD are often misdiagnosed.
“The cognitive decline [39] and psychiatric manifestations are often misdiagnosed [40,41,42].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [40]
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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy
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- Authors
- Rosebush, P. I., Garside, S., Levinson, A. J., & Mazurek, M. F.
- Affiliations
- McMaster University Medical Centre (CA)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 1999-08
- Volume
- 11
- Issue
- 3
- Pages
- 315-327
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2113182790
- Cited by
- 72
- References
- 7
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Keywords
- neuropsychiatric symptoms, mania, psychosis, cognitive impairment, inborn errors of metabolism, adrenal cortex, genetic counseling
- MeSH terms
- Addison Disease, Adolescent, Adrenoleukodystrophy, Adult, Mental Disorders, Child, Child, Preschool, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Age of Onset
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