Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis
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The two most common forms of X-linked adrenoleukodystrophy (X-ALD) are the cerebral forms (CER) with an inflammatory demyelinating reaction that resembles multiple sclerosis, and adrenomyeloneuropathy (AMN) which involves primarily the spinal cord and in which the inflammatory reaction is mild or absent. We found no significant association between the childhood cerebral form (CCER) or AMN and the human leukocyte (HLA) class I and Class II antigens including the class II DR2 haplotypes associated with multiple sclerosis. Inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta, interleukin-4, interleukin-6 and interferon-gamma) gene expression was increased in multiple sclerosis brain lesions, as has been reported previously, but much less so in CER brain lesions. These findings suggest that the pathogenesis of the inflammatory response in X-ALD differs from that in multiple sclerosis.
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Previous studies investigating the association of HLA type II haplotypes with cerebral involvement were not able to demonstrate significant associations.
“However, previous studies investigating this association were not able to demonstrate significant associations of certain HLA type II haplotypes with cerebral involvement.110–112”
From The genetic landscape of X-linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis (2015) · cites this paper as [112]
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- Authors
- McGuinness, M. C., Powers, J. M., Bias, W. B., Schmeckpeper, B. J., Segal, A. H., Gowda, V. C., Wesselingh, S. L., Berger, J., Griffin, D. E., & Smith, K. D.
- Affiliations
- Kennedy Krieger Institute (US)
- University of Rochester Medicine (US)
- Johns Hopkins University (US)
- University of Vienna (AT)
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 75
- Issue
- 1-2
- Pages
- 174-182
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2058456360
- Cited by
- 89
- References
- 45
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroimmunology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Center for Research Resources (RR 000 52)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24061, HD-10981, P30HD024061, P01HD010981)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- X-linked adrenoleukodystrophy, multiple sclerosis, cerebral adrenoleukodystrophy, adrenomyeloneuropathy, HLA-DR2, inflammatory demyelination, cytokine gene expression, TNF-α, IL-1β, IL-4, interleukin-6, interferon-gamma, pathogenesis
- MeSH terms
- Adrenoleukodystrophy, Blood Cells, Demyelinating Diseases, Encephalitis, HLA Antigens, Humans, Lymphocytes, Multiple Sclerosis, Tissue Distribution, Tumor Necrosis Factor-alpha, X Chromosome, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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