Cited by 89Multiple Sclerosis Research StudiesLysosomal Storage Disorders ResearchNeuroinflammation and Neurodegeneration Mechanisms

Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis

Open access
McGuinness, M.C, Powers, J.M, Bias, W.B, Schmeckpeper, B.J, Segal, A.H, Gowda, V.C, Wesselingh, S.L, Berger, J +2 more·1997·Journal of Neuroimmunology

Abstract

The two most common forms of X-linked adrenoleukodystrophy (X-ALD) are the cerebral forms (CER) with an inflammatory demyelinating reaction that resembles multiple sclerosis, and adrenomyeloneuropathy (AMN) which involves primarily the spinal cord and in which the inflammatory reaction is mild or absent. We found no significant association between the childhood cerebral form (CCER) or AMN and the human leukocyte (HLA) class I and Class II antigens including the class II DR2 haplotypes associated with multiple sclerosis. Inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta, interleukin-4, interleukin-6 and interferon-gamma) gene expression was increased in multiple sclerosis brain lesions, as has been reported previously, but much less so in CER brain lesions. These findings suggest that the pathogenesis of the inflammatory response in X-ALD differs from that in multiple sclerosis.

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Crossref · 10.1016/s0165-5728(97)00020-9

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Authors
McGuinness, M. C., Powers, J. M., Bias, W. B., Schmeckpeper, B. J., Segal, A. H., Gowda, V. C., Wesselingh, S. L., Berger, J., Griffin, D. E., & Smith, K. D.
Affiliations
  • Kennedy Krieger Institute (US)
  • University of Rochester Medicine (US)
  • Johns Hopkins University (US)
  • University of Vienna (AT)
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
1997-05
Volume
75
Issue
1-2
Pages
174-182
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2058456360
Cited by
89
References
45
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
3.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroimmunology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Center for Research Resources (RR 000 52)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD24061, HD-10981, P30HD024061, P01HD010981)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
X-linked adrenoleukodystrophy, multiple sclerosis, cerebral adrenoleukodystrophy, adrenomyeloneuropathy, HLA-DR2, inflammatory demyelination, cytokine gene expression, TNF-α, IL-1β, IL-4, interleukin-6, interferon-gamma, pathogenesis
MeSH terms
Adrenoleukodystrophy, Blood Cells, Demyelinating Diseases, Encephalitis, HLA Antigens, Humans, Lymphocytes, Multiple Sclerosis, Tissue Distribution, Tumor Necrosis Factor-alpha, X Chromosome, Cytokines

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