Impaired Set-Shifting Ability and Therapeutic Response in Obsessive-Compulsive Disorder
Open accessAbstract
Set-shifting ability and therapeutic response to serotonin reuptake inhibitors were investigated in 20 patients with obsessive-compulsive disorder. A clear relationship was found between impaired performance on two Wisconsin Card Sorting subtests (categories completed and perseverative errors) and positive treatment response.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is no consensus in the literature regarding the links between treatment resistance and OCD patients' alterations of cognitive functions.
“There is no consensus in the literature regarding the links between treatment resistance and OCD patients’ alterations of cognitive functions [37–41].”
From Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder (2026) · cites this paper as [41]
The Discussion (page unavailable) reports an association between impaired set-shifting and positive short-term treatment response in patients with OCD. It calls the study preliminary and says the authors knew of no previous report of that association, which supports uncertainty about the link. It does not assess a literature-wide consensus or specifically establish a link with treatment resistance. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1976) · Medical Entomology and Zoology · Cited by 8,899 · see citing works
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712 · see citing works
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,117 · see citing works
Wisconsin Card Sorting Test Manual – Revised and Expanded
Heaton, R. K., Chelune, C., Talley, J., Kay, G., & Curtiss, G. (1981) · Medical Entomology and Zoology · Cited by 2,975 · see citing works
Cognitive Deficits in Obsessive–Compulsive Disorder on Tests of Frontal–Striatal Function
Purcell, R., Maruff, P., Kyrios, M., & Pantelis, C. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00201-1 · Cited by 313 · see citing works
Dados normativos para o teste de fluência verbal categoria animais em nosso meio
Brucki, S. M. D., Malheiros, S. M. F., Okamoto, I. H., & Bertolucci, P. H. F. (1997) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x1997000100009 · Cited by 236 · see citing works
Lucey, J. V., Burness, C. E., Costa, D. C., Gacinovic, S., Pilowsky, L. S., Ell, P. J., Marks, I. M., & Kerwin, R. W. (1997) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1997.tb01916.x · Cited by 129 · see citing works
Frontal Lobe Dysfunction in Obsessive-Compulsive Disorder
Malloy, P. F. (2019) · Psychology Press eBooks · doi:10.4324/9781315788975-11 · Cited by 72 · see citing works
Not So Selective Serotonin Reuptake Inhibitors
Stahl, S. M. (1998) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v59n0701 · Cited by 63 · see citing works
Functional lateralization of the prefrontal cortex during traditional frontal lobe tasks
Horn, J. D. V., Berman, K. F., & Weinberger, D. R. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00249-9 · Cited by 23 · see citing works
Hollander, E., & Wong, C. M. (1996) · Neuropsychiatry, neuropsychology, and behavioral neurology · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Harvey NS: Impaired cognitive set-shifting in obsessive-com- pulsive disorder. IRCS Medical Science 1986; 14:936-937
- First MB, Spitzer RL, Gibbon M, et al: Structured Clinical Inter- view for DSM-IV Axis I Disorders: Patient Edition (SCID-I/P, Version 2.0). New York, Biometrics Research Department, New York State Psychiatric Institute, 1996
- Brucki SM, Malheiros SM, Okamoto IH, et al: Normative data on the verbal fluency test in the animal category in our milieu. Arq Neuropsiquiatr 1997; 55:56-61
Cited by
Sorted by citations
Dopaminergic control of cognitive flexibility in humans and animals
Klanker, M., Feenstra, M., & Denys, D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00201 · Cited by 209 · see citing works
Neuropsychological predictors of response to randomized treatment in obsessive–compulsive disorder
D'Alcante, C. C., Diniz, J. B., Fossaluza, V., Batistuzzo, M. C., Lopes, A. C., Shavitt, R. G., Deckersbach, T., Malloy-Diniz, L., Miguel, E. C., & Hoexter, M. Q. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.002 · Cited by 98 · see citing works
Neuropsychological function in obsessive-compulsive disorder
Tükel, R., Gürvit, H., Ertekin, B. A., Oflaz, S., Ertekin, E., Baran, B., Kalem, Ş. A., Kandemir, P. E., Özdemiroğlu, F. A., & Atalay, F. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.03.007 · Cited by 89 · see citing works
ROH, K. S., SHIN, M. S., KIM, M., HA, T., SHIN, Y., LEE, K. J., & KWON, J. S. (2005) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2005.01411.x · Cited by 86 · see citing works
A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey
Oikonomidis, L., Santangelo, A. M., Shiba, Y., Clarke, F. H., Robbins, T. W., & Roberts, A. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22446 · Cited by 54 · see citing works
Neurocognitive impairment does not predict treatment outcome in obsessive-compulsive disorder
Moritz, S., Kloss, M., Jacobsen, D., Fricke, S., Cuttler, C., Brassen, S., & Hand, I. (2005) · Behaviour Research and Therapy · doi:10.1016/j.brat.2004.06.012 · Cited by 33 · see citing works
Braga, D. T., Abramovitch, A., Fontenelle, L. F., Ferrão, Y. A., Gomes, J. B., Vivan, A. S., Ecker, K. K., Bortoncello, C. F., Mittelman, A., Miguel, E. C., et al. (2016) · Depression and Anxiety · doi:10.1002/da.22509 · Cited by 22 · see citing works
Self-citationDoolub, D., Vibert, N., Botta, F., Razmkon, A., Bouquet, C., Wassouf, I., Millet, B., Harika-Germaneau, G., & Jaafari, N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1017206 · Cited by 7 · see citing works
Wassouf, I., Vibert, N., Dampuré, J., Doolub, D., Harika-Germaneau, G., Langbour, N., & Jaafari, N. (2026) · Depression and Anxiety · doi:10.1155/da/9694689
“There is no consensus in the literature regarding the links between treatment resistance and OCD patients ’ alterations of cognitive functions [37 – 41].”
- Authors
- Fontenelle, L., Marques, C., Engelhardt, E., & Versiani, M.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Received July 19, 2000; revised October 19, 2000; accepted October 26, 2000. From the Anxiety and Depression Research Program, Institute of Psychiatry, Federal University of Rio de Janeiro (IPUB/UFRJ), and the Neuropsychology Section, Institute of Neurology Deolindo Couto, Federal University of Rio de Janeiro (INDC/UFRJ), Rio de Janeiro, Brazil. Address correspondence to Dr. Fontenelle, Rua Lopes Trovão 88 apt 1501 Bl. A-Icaraí-Niterói-RJ-Brazil-CEP 24220-071.
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2001-11
- Volume
- 13
- Issue
- 4
- Pages
- 508-510
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W1996757037
- Cited by
- 32
- References
- 11
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, set-shifting, executive function, Wisconsin Card Sorting Test, perseverative errors, serotonin reuptake inhibitors, treatment response, cognitive impairment
- MeSH terms
- Adult, Attention, Discrimination Learning, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Obsessive-Compulsive Disorder, Set, Psychology, Treatment Outcome, Selective Serotonin Reuptake Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
