NEUROPSYCHOLOGICAL PREDICTORS OF TREATMENT RESPONSE TO COGNITIVE BEHAVIORAL GROUP THERAPY IN OBSESSIVE-COMPULSIVE DISORDER: Research Article: Neuropsychological Predictors of Treatment Response
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BACKGROUND: The available research on the relationship between neuropsychological functioning and the therapeutic outcome of obsessive-compulsive disorder (OCD) has yielded inconsistent results. In this study, our aim was twofold. First, we sought to evaluate the effects of cognitive behavioral group therapy (CBGT) on neurocognitive functions in OCD patients. Second, we assessed the viability of neuropsychological test performance as a predictor of treatment response to CBGT. METHODS: One hundred fifty carefully screened OCD patients were randomized to receive either 12-week CBGT (n = 75) or to remain on a waiting list (WL; n = 75) for the corresponding time. Forty-seven participants dropped out of the study, leaving 103 participants that were included in the analysis (CBGT, n = 61; WL, n = 42). Participants had several neuropsychological domains evaluated both at baseline and at end-point. RESULTS: A significant difference in obsessive-compulsive, anxiety, and depression symptoms was observed between treated patients and controls favoring the CBGT group, but no significant differences were found on neuropsychological measures after 3 months of CBGT. In addition, there were no differences between treatment responders and nonresponders on all neuropsychological outcome measures. Employing a conservative alpha, neuropsychological test performance did not predict CBGT treatment response. CONCLUSIONS: Although the CBGT group demonstrated significant improvement in OCD symptoms, no significant difference was found on all neuropsychological domains, and test performance did not predict treatment response.
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There is no consensus in the literature regarding the links between treatment resistance and OCD patients' alterations of cognitive functions.
“There is no consensus in the literature regarding the links between treatment resistance and OCD patients’ alterations of cognitive functions [37–41].”
From Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder (2026) · cites this paper as [38]
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- Authors
- Braga, D. T., Abramovitch, A., Fontenelle, L. F., Ferrão, Y. A., Gomes, J. B., Vivan, A. S., Ecker, K. K., Bortoncello, C. F., Mittelman, A., Miguel, E. C., Trentini, C. M., & Cordioli, A. V.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- Department of Psychology; Texas State University; San Marcos Texas USA
- Universidade Federal do Rio de Janeiro (BR)
- Massachusetts General Hospital (US)
- Department of Psychiatry, Hospital de Clínicas de Porto Alegre; Universidade Federal do Rio Grande do Sul (UFRGS); Rio Grande do Sul (RS) Brazil
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Department of Psychiatry; University of São Paulo Faculty of Medicine; São Paulo (SP) Brazil
- Corresponding author
- Braga, Daniela T.
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-04-21
- Volume
- 33
- Issue
- 9
- Pages
- 848-861
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2337461001
- Cited by
- 22
- References
- 75
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 3 · 2020: 3 · 2018: 3 · 2017: 1 · 2016: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundação Instituto de Pesquisas Econômicas
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, group cognitive behavioral therapy, treatment response prediction, neuropsychological performance, neurocognitive function, predictors of treatment outcome, waitlist control, obsessive-compulsive symptoms, anxiety, depression
- MeSH terms
- Adult, Benzodiazepines, Combined Modality Therapy, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Obsessive-Compulsive Disorder, Psychometrics, Psychotherapy, Group, Antipsychotic Agents, Cognitive Behavioral Therapy, Treatment Outcome
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