The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?
Open accessAbstract
A review of pathological mechanisms that can explain the relationship between periodontitis and cardiovascular disease (CVD) is necessary to improve the management of both conditions. Metabolic syndrome is a combination of obesity, hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia, and dyslipidemia. All these have been examined in recent years in terms of their relationship to periodontitis. Reviewed data indicate an association between some of them (body mass index, high-density lipoprotein-cholesterol [HDL-C], triglycerides, high blood pressure, among others) and periodontitis. Oxidative stress may act as a potential common link to explain relationships between each component of metabolic syndrome and periodontitis. Both conditions show increased serum levels of products derived from oxidative damage, with a pro-inflammatory state likely influencing each other bidirectionally. Adipocytokines might modulate the oxidant/anti-oxidant balance in this relationship.
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Cites
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170
Inflammation: the link between insulin resistance, obesity and diabetes
Dandona, P. (2004) · Trends in Immunology · doi:10.1016/j.it.2003.10.013 · Cited by 2,170
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2003) · Diabetes · doi:10.2337/diabetes.52.1.1 · Cited by 1,482
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2005) · Diabetes Care · doi:10.2337/diacare.28.suppl_1.s37 · Cited by 830
Inflammatory mechanisms in the regulation of insulin resistance
Tilg, H., & Moschen, A. R. (2008) · Molecular Medicine · doi:10.2119/2007-00119.tilg · Cited by 779
Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb
Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666
Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia
Wright, E., Scism-Bacon, J. L., & Glass, L. C. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2006.00825.x · Cited by 517
Cited by
A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Taylor, J. J., Preshaw, P. M., & Lalla, E. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12059 · Cited by 425
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S., Suvan, J., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 298
Micronutritional approaches to periodontal therapy
Van der Velden, U., Kuzmanova, D., & Chapple, I. L. C. (2011) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01663.x · Cited by 199
Metadata
- Authors
- Bullon, P., Morillo, J. M., Ramirez-Tortosa, M. C., Quiles, J. L., Newman, H. N., & Battino, M.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2009-06
- Volume
- 88
- Issue
- 6
- Pages
- 503-518
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2038130959
- Cited by
- 267
- References
- 14
- FWCI
- 16.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.