The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Open accessAbstract
Aims: To review the evidence for the molecular and cellular processes that may potentially link periodontal disease and diabetes. The pathogenic roles of cytokines and metabolic molecules (e.g. glucose, lipids) are explored and the role of periodontal bacteria is also addressed. Paradigms for bidirectional relationships between periodontitis and diabetes are discussed and opportunities for elaborating these models are considered. Methods: Database searches were performed using MeSH terms, keywords, and title words. Studies were evaluated and summarized in a narrative review. Results: Periodontal microbiota appears unaltered by diabetes and there is little evidence that it may influence glycaemic control. Small‐scale clinical studies and experiments in animal models suggest that IL‐1β, TNF‐α, IL‐6, OPG and RANKL may mediate periodontitis in diabetes. The AGE‐RAGE axis is likely an important pathway of tissue destruction and impaired repair in diabetes‐associated periodontitis. A role for locally activated pro‐inflammatory factors in the periodontium, which subsequently impact on diabetes, remains speculative. Conclusion: There is substantial information on potential mechanistic pathways which support a close association between diabetes and periodontitis, but there is a real need for longitudinal clinical studies using larger patient groups, integrated with studies of animal models and cells/tissues in vitro.
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Cites
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
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Type 2 diabetes as an inflammatory disease
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Periodontal Disease and Diabetes Mellitus: A Two‐Way Relationship
Grossi, S. G., & Genco, R. J. (1998) · Annals of Periodontology · doi:10.1902/annals.1998.3.1.51 · Cited by 842
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
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Cited by
Chapple, I. L. C., Genco, R., & on behalf of working group 2 of the joint EFP/AAP workshop (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340011 · Cited by 852
Chapple, I. L. C., Bouchard, P., Cagetti, M. G., Campus, G., Carra, M., Cocco, F., Nibali, L., Hujoel, P., Laine, M. L., Lingström, P., et al. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12685 · Cited by 488
An update on the evidence for pathogenic mechanisms that may link periodontitis and diabetes
Polak, D., & Shapira, L. (2018) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12803 · Cited by 396
Diabetes mellitus related bone metabolism and periodontal disease
Wu, Y.-Y., Xiao, E., & Graves, D. T. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2015.2 · Cited by 310
Albandar, J. M., Susin, C., & Hughes, F. J. (2018) · Journal of Periodontology · doi:10.1002/jper.16-0480 · Cited by 253
Metadata
- Authors
- Taylor, J. J., Preshaw, P. M., & Lalla, E.
- Venue
- Journal of Clinical Periodontology
- Publisher
- Wiley
- Published
- 2013-04
- Volume
- 40
- Issue
- s14
- Pages
- S113-34
- ISSN
- 0303-6979 (ISSN-L)
- 1600-051X
- OpenAlex
- W2105417993
- Cited by
- 425
- References
- 9
- FWCI
- 41.11
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
