The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints
Abstract
Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the destruction of tooth-supporting structures, being the presence of periodontopathogens required, but not sufficient, for disease development. As a general rule, host inflammatory mediators have been associated with tissue destruction, while anti-inflammatory mediators counteract and attenuate disease progression. With the discovery of several T-cell subsets bearing distinct immunoregulatory properties, this pro- vs. anti-inflammatory scenario became more complex, and a series of studies has hypothesized protective or destructive roles for Th1, Th2, Th17, and Treg subpopulations of polarized lymphocytes. Interestingly, the “protective vs. destructive” archetype is usually considered in a framework related to tissue destruction and disease progression. However, it is important to remember that periodontal diseases are infectious inflammatory conditions, and recent studies have demonstrated that cytokines (TNF-α and IFN-γ) considered harmful in the context of tissue destruction play important roles in the control of periodontal infection. Therefore, in this review, the state-of-the-art knowledge concerning the protective and destructive roles of host inflammatory immune response will be critically evaluated and discussed from the tissue destruction and control-of-infection viewpoints.
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Cites
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Cited by
Inflammatory and immune pathways in the pathogenesis of periodontal disease
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Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
Kitaura, H., Marahleh, A., Ohori, F., Noguchi, T., Shen, W.-R., Qi, J., Nara, Y., Pramusita, A., Kinjo, R., & Mizoguchi, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145169 · Cited by 380
Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
Cheng, R., Wu, Z., Li, M., Shao, M., & Hu, T. (2020) · International Journal of Oral Science · doi:10.1038/s41368-019-0068-8 · Cited by 298
The association of periodontal diseases with metabolic syndrome and obesity
Jepsen, S., Suvan, J., & Deschner, J. (2020) · Periodontology 2000 · doi:10.1111/prd.12326 · Cited by 298
Metadata
- Authors
- Garlet, G. P.
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2010-08-25
- Volume
- 89
- Issue
- 12
- Pages
- 1349-1363
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2120741277
- Cited by
- 720
- References
- 192
- FWCI
- 41.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Garlet, G. P. (2010). Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints. Journal of Dental Research. https://doi.org/10.1177/0022034510376402
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