The DOI matches its Crossref record; 216 of the 216 references it cites were found in a registry or an index.
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
Open accessAbstract
The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type. Osteoclasts derived from the hematopoietic stem cell lineage are the principal cells involved in bone resorption. In osteolytic diseases such as rheumatoid arthritis, periodontitis, and osteoporosis, the balance is lost and changes in favor of bone resorption. Therefore, it is vital to elucidate the mechanisms of osteoclast formation and bone resorption. It has been reported that osteocytes express Receptor activator of nuclear factor κΒ ligand (RANKL), an essential factor for osteoclast formation. RANKL secreted by osteocytes is the most important factor for physiologically supported osteoclast formation in the developing skeleton and in pathological bone resorption such as experimental periodontal bone loss. TNF-α directly enhances RANKL expression in osteocytes and promotes osteoclast formation. Moreover, TNF-α enhances sclerostin expression in osteocytes, which also increases osteoclast formation. These findings suggest that osteocyte-related cytokines act directly to enhance osteoclast formation and bone resorption. In this review, we outline the most recent knowledge concerning bone resorption-related cytokines and discuss the osteocyte as the master regulator of bone resorption and effector in osteoclast formation.
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Cites
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Cited by
Role and Regulation of Transcription Factors in Osteoclastogenesis
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Osteocyte mechanotransduction in orthodontic tooth movement
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A review of mathematical modeling of bone remodeling from a systems biology perspective
Cook, C. V., Lighty, A. M., Smith, B. J., & Ford Versypt, A. N. (2024) · Frontiers in Systems Biology · doi:10.3389/fsysb.2024.1368555 · Cited by 25
Sclerostin in excessive drinkers: relationships with liver function and body composition
Martín González, C., Fernández Rodríguez, C. M., Abreu González, P., García Rodríguez, A., Alvisa Negrín, J. C., Cabañas Perales, E., González Navarrete, L., Vera Delgado, V. E., Ortega Toledo, P., & González Reimers, E. (2022) · Nutrients · doi:10.3390/nu14132574 · Cited by 9
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts
Lademann, F., Rijntjes, E., Köhrle, J., Tsourdi, E., Hofbauer, L. C., & Rauner, M. (2024) · Communications Biology · doi:10.1038/s42003-024-06227-0 · Cited by 8
Metadata
- Authors
- Kitaura, H., Marahleh, A., Ohori, F., Noguchi, T., Shen, W.-R., Qi, J., Nara, Y., Pramusita, A., Kinjo, R., & Mizoguchi, I.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-07-21
- Volume
- 21
- Issue
- 14
- Pages
- 5169
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3045012095
- Cited by
- 380
- References
- 216
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- gold
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