Local Inflammatory Markers and Systemic Endotoxin in Aggressive Periodontitis
Open accessAbstract
While much research has focused on local and systemic factors contributing to periodontal disease, little is known regarding mechanisms linking these factors. We have previously reported a systemic hyper-inflammatory response to bacterial endotoxin in localized aggressive periodontitis (LAP). The objectives of this study were to delineate cyto/chemokines in gingival crevicular fluid (GCF) and evaluate systemic levels of endotoxin associated with LAP. Clinical parameters, GCF, and peripheral blood were collected from: 34 LAP, 10 healthy siblings, and nine healthy unrelated control individuals. Cyto/chemokines were quantified in GCF, systemic endotoxin levels were quantified in plasma, and correlation analysis was performed among all parameters. Nine mediators were elevated in LAP diseased sites as compared with healthy sites (TNFα, INFγ, IL1β, IL2, IL6, IL10, Il12p40, GMCSF, and MIP1α, p < 0.001), while MCP1, IL4, and IL8 were elevated in healthy sites (p < 0.01). Four- to five-fold-higher endotoxin levels were detected in LAP plasma compared with that from healthy participants (p < 0.0001), which correlated with all clinical parameters and most cyto/chemokines analyzed. In conclusion, higher systemic levels of endotoxin were found in LAP, which correlates with an exacerbated local inflammatory response and clinical signs of disease. (Clinicaltrials.gov number, NCT01330719).
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People with chronic gum disease (periodontitis) have elevated blood endotoxin, a higher risk of Alzheimer's disease and a faster rate of cognitive decline.
“People with chronic gum disease (periodontitis) have elevated blood endotoxin [85, 86], a higher risk of Alzheimer’s disease and a faster rate of cognitive decline [87].”
From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [86]
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The endotoxin hypothesis of neurodegeneration
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- Authors
- Shaddox, L. M., Wiedey, J., Calderon, N. L., Magnusson, I., Bimstein, E., Bidwell, J. A., Zapert, E. F., Aukhil, I., & Wallet, S. M.
- Affiliations
- University of Florida Health (US)
- University of Florida (US)
- Leon County Health Department, Tallahassee, Florida
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2011-07-05
- Volume
- 90
- Issue
- 9
- Pages
- 1140-1144
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- PMC
- PMC3169885
- OpenAlex
- W2167527079
- Cited by
- 95
- References
- 16
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 13 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 9 · 2012: 3
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Dental Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Association for Dental Research
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE019456)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- aggressive periodontitis, localized aggressive periodontitis, gingival crevicular fluid, bacterial endotoxin, cytokines, chemokines, local inflammation, systemic inflammation, TNF-α, interleukin-6, IL-10, IL-12, interferon-gamma, periodontal disease
- MeSH terms
- Adolescent, Black or African American, Child, Child, Preschool, Female, Gingival Crevicular Fluid, Humans, Interferon-gamma, Interleukins, Lipopolysaccharides, Male, Aggressive Periodontitis, Regression Analysis, Tumor Necrosis Factor-alpha, Biomarkers, Case-Control Studies, Granulocyte-Macrophage Colony-Stimulating Factor, Cytokines, Statistics, Nonparametric, Adaptor Proteins, Signal Transducing, Young Adult
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