Oral Health Behavior and Metabolic Syndrome and Its Components in Adults
Abstract
Inflammation has been strongly related to metabolic syndrome (MetS). Periodontal disease is the most common chronic infection in adults. We investigated a cross-sectional (n = 925) and 3-year longitudinal (n = 685) relationship between the daily frequency of toothbrushing and MetS. In the cross-sectional analysis, the prevalence of MetS was 15.7%. After adjustment for potential confounding factors (including all lifestyle factors), the odds ratios (95% confidence interval [CI]) of having MetS in those who brushed 2 times/day and ≥ 3 times/day were 0.71 (0.48-1.05) and 0.47 (0.24-0.92), respectively, as compared with ratios in those with a toothbrushing frequency of ≤ 1 time/day. Increasing toothbrushing frequency tended to relate inversely to hypertriglyceridemia and high-sensitivity C-reactive protein. In the longitudinal analysis, 99 participants were newly diagnosed with MetS. The adjusted odds ratios (95% CI) of the MetS in participants who brushed 2 times/day and ≥ 3 times/day as compared with participants who brushed ≤ 1 time/day were 0.80 (0.49-1.31) and 0.43 (0.19-0.97), respectively. The frequency of toothbrushing was related inversely only to hypertriglyceridemia, consistent with the cross-sectional analysis. This study found that more frequent toothbrushing is related to a lower prevalence and incidence of MetS. These results suggest that more frequent toothbrushing may contribute to the prevention of MetS due to the inflammation/triglyceride pathway.
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The same metabolic syndrome pathway occurs in periodontitis, psoriasis, celiac disease, obesity, COPD, and rheumatoid arthritis.
“The same pathway has also been shown to occur in paraodontitis,118 psoriasis,119 celiac disease,120 obesity,121, 122 COPD,123, 124 and rheumatoid arthritis.125”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [118]
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Hypoalbuminemia: Pathogenesis and Clinical Significance
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- Authors
- Kobayashi, Y., Niu, K., Guan, L., Momma, H., Guo, H., Cui, Y., & Nagatomi, R.
- Affiliations
- Tohoku University (JP)
- Venue
- Journal of Dental Research
- Publisher
- SAGE Publications
- Published
- 2012-05
- Volume
- 91
- Issue
- 5
- Pages
- 479-484
- ISSN
- 0022-0345 (ISSN-L)
- 1544-0591
- OpenAlex
- W2113272688
- Cited by
- 72
- References
- 33
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 2 · 2013: 9 · 2012: 1
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- toothbrushing frequency, metabolic syndrome, oral health behavior, hypertriglyceridemia, C-reactive protein, inflammation, periodontal disease, metabolic syndrome prevention, adults
- MeSH terms
- Adult, Analysis of Variance, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Japan, Cholesterol, LDL, Longitudinal Studies, Male, Risk Factors, Toothbrushing, Hypertriglyceridemia, Health Behavior, Confidence Intervals, Logistic Models, Odds Ratio, Metabolic Syndrome, Chronic Periodontitis, Self Report
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