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New Frontiers in Gold Labeling
Open accessAbstract
Recent advances in gold technology have led to probes with improved properties and performance for cell biologists: higher labeling density, better sensitivity, and greater penetration into tissues. Gold clusters, such as the 1.4-nm Nanogold, are gold compounds that can be covalently linked to Fab′ antibody fragments, making small and stable probes. Silver enhancement then makes these small gold particles easily visible by EM, LM, and directly by eye. Another advance is the combination of fluorescent and gold probes for correlative microscopy. Chemical crosslinking of gold particles to many biologically active molecules has made possible many novel probes, such as gold-lipids, gold-Ni-NTA, and gold-ATP.
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Cites
Chen, S., & Kimura, K. (1999) · Langmuir · doi:10.1021/la9812828 · Cited by 362
Cited by
Ghosh, S. K., & Pal, T. (2007) · Chemical Reviews · doi:10.1021/cr0680282 · Cited by 2,782
Fundamentals and application of magnetic particles in cell isolation and enrichment: a review
Plouffe, B. D., Murthy, S. K., & Lewis, L. H. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/1/016601 · Cited by 334
Magnetite nanoparticles with tunable gold or silver shell
Mandal, M., Kundu, S., Ghosh, S. K., Panigrahi, S., Sau, T. K., Yusuf, S. M., & Pal, T. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.01.013 · Cited by 287
Integrating diverse data for structure determination of macromolecular assemblies
Alber, F., Förster, F., Korkin, D., Topf, M., & Sali, A. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.060407.135530 · Cited by 206
Nanotechnology-based electrochemical sensors for biomonitoring chemical exposures
Barry, R. C., Lin, Y., Wang, J., Liu, G., & Timchalk, C. A. (2009) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2008.71 · Cited by 73
Metadata
- Authors
- Hainfeld, J. F., & Powell, R. D.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2000-04
- Volume
- 48
- Issue
- 4
- Pages
- 471-480
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2170473509
- Cited by
- 250
- References
- 1
- FWCI
- 7.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
