The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
SPARC, a Matricellular Glycoprotein with Important Biological Functions
Open accessAbstract
SPARC (secreted protein, acidic and rich in cysteine) is a unique matricellular glycoprotein that is expressed by many different types of cells and is associated with development, remodeling, cell turnover, and tissue repair. Its principal functions in vitro are counteradhesion and antiproliferation, which proceed via different signaling pathways. SPARC consists of three domains, each of which has independent activity and unique properties. The extracellular calcium binding module and the follistatin-like module have been recently crystallized. Specific interactions between SPARC and growth factors, extracellular matrix proteins, and cell surface proteins contribute to the diverse activities described for SPARC in vivo and in vitro. The location of SPARC in the nuclear matrix of certain proliferating cells, but only in the cytosol of postmitotic neurons, indicates potential functions of SPARC as a nuclear protein, which might be involved in the regulation of cell cycle progression and mitosis. High levels of SPARC have been found in adult eye, and SPARC-null mice exhibit cataracts at 1–2 months of age. This animal model provides an excellent opportunity to confirm and explore some of the properties of SPARC, to investigate cataractogenesis, and to study SPARC-related family proteins, e.g., SC1/hevin, a counteradhesive matricellular protein that might functionally compensate for SPARC in certain tissues.
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Self-citationSPARC, a matricellular protein: at the crossroads of cell–matrix communication
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Self-citationExtracellular Matrix Molecules: Potential Targets in Pharmacotherapy
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Metadata
- Authors
- Yan, Q., & Sage, E. H.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 1999-12
- Volume
- 47
- Issue
- 12
- Pages
- 1495-1505
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- OpenAlex
- W2137331183
- Cited by
- 379
- References
- 75
- FWCI
- 8.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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