An analogue computer model for the insulin response to glucose infusion
Abstract
An analogue computer model has been constructed for the analysis of the interrelationship between blood glucose and plasma insulin concentrations during glucose infusion. The model presented gives quantitative information on the effect of plasma insulin on glucose uptake, the total amount of glucose taken up by the tissues at a given time, the effect of blood glucose on the release of stored and newly formed insulin, and the rapidity by which plasma insulin is increased in response to hyperglycaemia. Such an analogue computer model might be a useful tool in the investigation of the various dynamic factors involved in the glucose- insulin interrelationship.
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The action of insulin on glucose production is a reflection of insulin concentration in the extracellular space, rather than in blood.
“The action of insulin on glucose production is a reflection of insulin concentration in the extracellular space, rather than in blood [26].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [26]
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(1977) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1977.tb07621.x
- Authors
- Cerasi, E., & Andersson, B.
- Affiliations
- Karolinska University Hospital (SE)
- ORCID
- Cerasi, Erol
- Venue
- SIMULATION
- Publisher
- SAGE Publications
- Published
- 1971-06
- Volume
- 16
- Issue
- 6
- Pages
- 243-255
- ISSN
- 0037-5497 (ISSN-L)
- 1741-3133
- OpenAlex
- W2043162493
- Cited by
- 24
- References
- 28
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- SIMULATION (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin, glucose infusion, blood glucose, plasma insulin, glucose uptake, insulin secretion, hyperglycemia
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