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Cited by 38Ginkgo biloba and Cashew ApplicationsCholinesterase and Neurodegenerative DiseasesComplementary and Alternative Medicine Studies

The Effects of Ginkgo biloba Extracts on the Pharmacokinetics and Pharmacodynamics of Donepezil

Yasui‐Furukori, Norio, Furukori, Hanako, Kaneda, Ayako, Kaneko, Sunao, Tateishi, Tomonori·2004·The Journal of Clinical Pharmacology
DOI 10.1177/0091270004264161
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Abstract

The effects of ginkgo supplementation on the steady-state plasma concentration of donepezil and the activity of cholinesterase in red blood cells and cognitive function were examined. Fourteen inpatients with Alzheimer's disease received donepezil 5 mg/day, supplemented with extracts of Ginkgo biloba 90 mg/day for 30 days. Blood samples were collected before and during ginkgo supplementation and 30 days after its discontinuation, together with an assessment of cognitive function. Plasma drug concentration was measured using high-performance liquid chromatography (HPLC), and cholinesterase in red blood cells was measured using Ellman methods. Cognitive function was evaluated using the Mini-Mental Scale Examination (MMSE). Plasma concentration of donepezil during ginkgo supplementation (mean +/- SD [95% confidence interval]; 24.4 +/- 12.6 ng/mL [17.1-31.7 ng/mL]) was not significantly different from that before ginkgo supplementation (22.7 +/- 10.3 ng/mL [16.8-28.7 ng/mL]) or that 4 weeks after its discontinuation (25.0 +/- 12.9 ng/mL [17.6-32.4 ng/mL]). There was no significant difference between cholinesterase in red blood cells before ginkgo supplementation (1.75 +/- 0.21 U [1.63-1.87 U]), during ginkgo supplementation (1.91 +/- 0.27 U [1.76-2.07 U]), and 4 weeks after its discontinuation (1.83 +/- 0.29 U [1.66-2.00 U]). Ginkgo supplementation did not alter MMSE scores throughout the study. The present study shows that ginkgo supplementation does not have major impact on the pharmacokinetics and pharmacodynamics of donepezil.

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  • There is a scarcity of reports of adverse events and interactions caused by herbal medicines, especially among Alzheimer's disease patients.

    “there exists a scarcity of reports of adverse events and interactions caused by these groups of agents, especially among AD patients.”

    From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [111]

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Authors
Yasui‐Furukori, N., Furukori, H., Kaneda, A., Kaneko, S., & Tateishi, T.
Affiliations
Hirosaki University (JP)
Corresponding author
Yasui‐Furukori, Norio
ORCID
Yasui‐Furukori, Norio
Venue
The Journal of Clinical Pharmacology
Publisher
Wiley
Published
2004-05
Volume
44
Issue
5
Pages
538-542
ISSN
  • 0021-9754 (ISSN-L)
  • 0091-2700
  • 1552-4604
DOI
10.1177/0091270004264161
OpenAlex
W2113464174
Cited by
38
References
21
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 1 · 2018: 1 · 2016: 1 · 2014: 2 · 2013: 1 · 2012: 6
FWCI
8.31
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3233 d)
Locations
  • The Journal of Clinical Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords
Ginkgo biloba extract, donepezil, pharmacokinetics, pharmacodynamics, Alzheimer's disease, cholinesterase activity, erythrocytes, cognitive function, drug interactions, plasma drug concentration, cholinesterase inhibitors
MeSH terms
Donepezil, Administration, Oral, Aged, Alzheimer Disease, Cholinesterase Inhibitors, Cholinesterases, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Interactions, Drug Therapy, Combination, Erythrocytes, Female, Humans, Indans, Male, Phytotherapy, Mental Status Schedule, Piperidines, Plant Extracts, Plants, Medicinal, Time Factors, Plant Leaves, Ginkgo biloba

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