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The Contribution of P‐glycoprotein to Pharmacokinetic Drug‐Drug Interactions
Abstract
P‐glycoprotein (PGP) is well known because of its contribution to multiple‐drug resistance during anticancer treatment. More recent work indicates that PGP mediates the transcellular transport of many drugs in addition to anticancer compounds. Because of this reason, its potential role in clinically significant drug‐drug interactions has just begun to be realized. This article provides an overview of published in vitro, in situ, and in vivo drug‐drug interaction results that are related to PGP transport so that the awareness of the scientific community can be heightened. In addition, several recommendations are made to take full advantage of the recently published data.
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Cited by
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Xie, H.-G., Kim, R. B., Wood, A. J., & Stein, C. M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.815 · Cited by 600
Impact of Drug Transporter Studies on Drug Discovery and Development
Mizuno, N., Niwa, T., Yotsumoto, Y., & Sugiyama, Y. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.1 · Cited by 490
Inhibition of the Multidrug Resistance P-Glycoprotein: Time for a Change of Strategy?
Callaghan, R., Luk, F., & Bebawy, M. (2014) · Drug Metabolism and Disposition · doi:10.1124/dmd.113.056176 · Cited by 453
Remimazolam: non-clinical and clinical profile of a new sedative/anesthetic agent
Kilpatrick, G. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.690875 · Cited by 262
A Comparison of Pharmacokinetics between Humans and Monkeys
Akabane, T., Tabata, K., Kadono, K., Sakuda, S., Terashita, S., & Teramura, T. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.109.028829 · Cited by 97
Metadata
- Authors
- Yu, D. K.
- Venue
- The Journal of Clinical Pharmacology
- Publisher
- Wiley
- Published
- 1999-12
- Volume
- 39
- Issue
- 12
- Pages
- 1203-1211
- ISSN
- 0021-9754 (ISSN-L)
- 0091-2700
- 1552-4604
- OpenAlex
- W2126310184
- Cited by
- 199
- References
- 0
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, D. K. (1999). The Contribution of P‐glycoprotein to Pharmacokinetic Drug‐Drug Interactions. The Journal of Clinical Pharmacology. https://doi.org/10.1177/00912709922012006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
