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Cited by 107Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsImmune responses and vaccinations

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Effects of prebiotics on the immune response to vaccination in the elderly

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Bunout, D, Hirsch, S, de la Maza, MP, Munoz, C, Haschke, F, Steenhout, P, Klassen, P, Barrera, G, Gattas, V, Petermann, M·2002·Journal of Parenteral and Enteral Nutrition
DOI 10.1177/0148607102026006372
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Abstract

BACKGROUND: Prebiotics stimulate the growth of bifidogenic bacteria in the gut. The aim of this work was to assess the effects of a prebiotic mixture on the immune response in healthy elderly people. METHODS: Healthy free-living elderly people (age, > or = 70 years), receiving a nutritional supplement that provided 1.6 MJ, 15 g of protein, and 50% of vitamin daily reference values per day, were randomly assigned to receive a prebiotic mixture (6 g/d of a 70% raftilose and 30% raftiline mixture) or placebo (6 g of maltodextrin powder) for 28 weeks. At week 2 of the study, all subjects were vaccinated with influenza and pneumococcal vaccines. At weeks 0, 2, and 8 of the study, serum total proteins, albumin, immunoglobulins, saliva secretory immunoglobulin A (IgA), and serum titers of influenza A and B and pneumococcal antibodies were measured. At week 8, cultured peripheral monocyte cell secretion of interleukin-4, interferon-gamma, and lymphocyte proliferation, stimulated with phytohemagglutinin and influenza antigen, were measured. RESULTS: Sixty-six subjects were considered eligible for the study, and 43 (20 receiving prebiotics and 23 receiving placebo) were considered for final analyses on a per protocol basis. No changes in serum proteins, albumin, immunoglobulins, and secretory IgA were observed. Antibodies against influenza B and pneumococcus increased significantly from weeks 0 to 8, with no significant differences between groups. Antibodies against influenza A did not increase. No effects of prebiotics on interleukin-4 and interferon-gamma secretion by cultured monocytes were observed. CONCLUSIONS: No immunological effects of prebiotics were observed in this study.

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Research works printed but not linked: 2

  1. McDowell I, Newell C: Measuring Health. A Guide to Rating Scales and Questionnaires. Oxford University Press, New York, 1996
  2. Moore RA, Wiffen PJ, Lipsky BA: Are the pneumococcal polysac- charide vaccines effective. Meta-analysis of the prospective trials. BMC Fam Pract 1:1, 2000 www.biomedcentral.com/ bmcfampract

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Metadata

Authors
Bunout, D., Hirsch, S., de la Maza, M., Munoz, C., Haschke, F., Steenhout, P., Klassen, P., Barrera, G., Gattas, V, & Petermann, M.
Affiliations
  • University of Chile (CL)
  • National Agricultural Technology Institute (AR)
ORCID
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
2002-11
Volume
26
Issue
6
Pages
372-376
ISSN
  • 0148-6071 (ISSN-L)
  • 1941-2444
DOI
10.1177/0148607102026006372
OpenAlex
W2030975061
Cited by
107
References
9
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 4
FWCI
2.63
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Parenteral and Enteral Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Nestec
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
prebiotics, vaccine response, older adults, influenza vaccination, pneumococcal vaccine, secretory IgA, immunoglobulins, antibody response, IL-4, interferon-gamma, monocytes, lymphocyte proliferation, dietary supplements
MeSH terms
Aged, Analysis of Variance, Antibody Formation, Blood Proteins, Female, Humans, Immunoglobulins, Influenza Vaccines, Lymphocytes, Male, Reference Values, Time Factors, Vaccination, Cytokines, Dietary Supplements, Probiotics, Pneumococcal Vaccines

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