Cited by 107Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsImmune responses and vaccinations

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Effects of prebiotics on the immune response to vaccination in the elderly

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Bunout, D, Hirsch, S, de la Maza, MP, Munoz, C, Haschke, F, Steenhout, P, Klassen, P, Barrera, G, Gattas, V, Petermann, M·2002·Journal of Parenteral and Enteral Nutrition

DOI 10.1177/0148607102026006372

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Abstract

BACKGROUND: Prebiotics stimulate the growth of bifidogenic bacteria in the gut. The aim of this work was to assess the effects of a prebiotic mixture on the immune response in healthy elderly people. METHODS: Healthy free-living elderly people (age, > or = 70 years), receiving a nutritional supplement that provided 1.6 MJ, 15 g of protein, and 50% of vitamin daily reference values per day, were randomly assigned to receive a prebiotic mixture (6 g/d of a 70% raftilose and 30% raftiline mixture) or placebo (6 g of maltodextrin powder) for 28 weeks. At week 2 of the study, all subjects were vaccinated with influenza and pneumococcal vaccines. At weeks 0, 2, and 8 of the study, serum total proteins, albumin, immunoglobulins, saliva secretory immunoglobulin A (IgA), and serum titers of influenza A and B and pneumococcal antibodies were measured. At week 8, cultured peripheral monocyte cell secretion of interleukin-4, interferon-gamma, and lymphocyte proliferation, stimulated with phytohemagglutinin and influenza antigen, were measured. RESULTS: Sixty-six subjects were considered eligible for the study, and 43 (20 receiving prebiotics and 23 receiving placebo) were considered for final analyses on a per protocol basis. No changes in serum proteins, albumin, immunoglobulins, and secretory IgA were observed. Antibodies against influenza B and pneumococcus increased significantly from weeks 0 to 8, with no significant differences between groups. Antibodies against influenza A did not increase. No effects of prebiotics on interleukin-4 and interferon-gamma secretion by cultured monocytes were observed. CONCLUSIONS: No immunological effects of prebiotics were observed in this study.

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Authors: Bunout, D., Hirsch, S., de la Maza, M., Munoz, C., Haschke, F., Steenhout, P., Klassen, P., Barrera, G., Gattas, V, & Petermann, M.
Affiliations: University of Chile (CL)
National Agricultural Technology Institute (AR)
ORCID: Bunout, D
Klassen, P
Venue: Journal of Parenteral and Enteral Nutrition
Publisher: Wiley
Published: 2002-11
Volume: 26
Issue: 6
Pages: 372-376
ISSN: 0148-6071 (ISSN-L)
1941-2444
DOI: 10.1177/0148607102026006372
OpenAlex: W2030975061
Cited by: 107
References: 9
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 4
FWCI: 2.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Parenteral and Enteral Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Nestec
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: prebiotics, vaccine response, older adults, influenza vaccination, pneumococcal vaccine, secretory IgA, immunoglobulins, antibody response, IL-4, interferon-gamma, monocytes, lymphocyte proliferation, dietary supplements
MeSH terms: Aged, Analysis of Variance, Antibody Formation, Blood Proteins, Female, Humans, Immunoglobulins, Influenza Vaccines, Lymphocytes, Male, Reference Values, Time Factors, Vaccination, Cytokines, Dietary Supplements, Probiotics, Pneumococcal Vaccines

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Effects of prebiotics on the immune response to vaccination in the elderly

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