Cited by 236Antioxidant Activity and Oxidative StressExercise and Physiological ResponsesRedox biology and oxidative stress

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Oxidative Stress

Preiser, Jean‐Charles·2012·Journal of Parenteral and Enteral Nutrition

DOI 10.1177/0148607111434963

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Abstract

Oxidative stress is defined by an imbalance between increased levels of reactive oxygen species (ROS) and a low activity of antioxidant mechanisms. An increased oxidative stress can induce damage to the cellular structure and potentially destroy tissues. However, ROS are needed for adequate cell function, including the production of energy by the mitochondria. Increased oxidative stress has been incriminated in physiological conditions, such as aging and exercise, and in several pathological conditions, including cancer, neurodegenerative diseases, cardiovascular diseases, diabetes, inflammatory diseases, and intoxications. However, prevention by antioxidants has been mostly inefficient. Therefore, a rigorous scientific evaluation in well‐defined conditions is mandatory to define the appropriate place for manipulations of the oxidative pathways in human medicine.

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Authors: Preiser, J.
Affiliations: Erasmus Hospital (BE)
Corresponding author: Preiser, Jean‐Charles
ORCID: Preiser, Jean‐Charles
Venue: Journal of Parenteral and Enteral Nutrition
Publisher: Wiley
Published: 2012-02
Volume: 36
Issue: 2
Pages: 147-154
ISSN: 0148-6071 (ISSN-L)
1941-2444
DOI: 10.1177/0148607111434963
OpenAlex: W4246769188
Cited by: 236
References: 43
Citations by year: 2026: 29 · 2025: 43 · 2024: 35 · 2023: 30 · 2022: 21 · 2021: 14 · 2020: 14 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 5 · 2012: 2
FWCI: 4.68
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Parenteral and Enteral Nutrition (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: oxidative stress, reactive oxygen species, antioxidants, mitochondrial energy production, aging, physical activity, cancer, neurodegenerative diseases, cardiovascular disease, diabetes mellitus, inflammation, poisoning, antioxidant therapy
MeSH terms: Antioxidants, Humans, Oxidation-Reduction, Reactive Oxygen Species, Oxidative Stress

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