The neglected significance of “antioxidative stress”

Poljsak, B.; Milisav, I.

doi:10.1155/2012/480895

Cited by 177Antioxidant Activity and Oxidative StressRedox biology and oxidative stressExercise and Physiological Responses

The neglected significance of “antioxidative stress”

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Poljsak, B., Milisav, I.·2012·Oxidative Medicine and Cellular Longevity

DOI 10.1155/2012/480895PMC PMC3357598

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Abstract

Oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species (ROS) in favor of the prooxidant balance, leading to potential oxidative damage. ROSs were considered traditionally to be only a toxic byproduct of aerobic metabolism. However, recently, it has become apparent that ROS might control many different physiological processes such as induction of stress response, pathogen defense, and systemic signaling. Thus, the imbalance of the increased antioxidant potential, the so-called antioxidative stress, should be as dangerous as well. Here, we synthesize increasing evidence on "antioxidative stress-induced" beneficial versus harmful roles on health, disease, and aging processes. Oxidative stress is not necessarily an un-wanted situation, since its consequences may be beneficial for many physiological reactions in cells. On the other hand, there are potentially harmful effects of "antioxidative stress," especially in the cases of overconsumption of synthetic antioxidants. Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging.

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According to the mitohormesis hypothesis, moderate amounts of ROS may be physiologically beneficial whilst excess amounts may have a detrimental effect.
“Mitohormesis could provide one potential explanation for the observations discussed above, as according to this hypothesis, moderate amounts of ROS may be physiologically beneficial whilst excess amounts may have a detrimental effect [19,54].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [54]

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Authors: Poljsak, B., & Milisav, I.
Affiliations: Laboratory of Oxidative Stress Research, Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, SI-1000 Ljubljana, Slovenia
University of Ljubljana (SI)
Corresponding author: Milisav, I.
ORCID: Milisav, I.
Venue: Oxidative Medicine and Cellular Longevity
Publisher: Hindawi Limited
Published: 2012
Volume: 2012
Pages: 1-12
ISSN: 1942-0994 (ISSN-L)
1942-0900
DOI: 10.1155/2012/480895
PMC: PMC3357598
OpenAlex: W2065681289
Cited by: 177
References: 173
Citations by year: 2026: 9 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 6 · 2017: 13 · 2016: 6 · 2015: 16 · 2014: 13 · 2013: 16 · 2012: 6
FWCI: 1.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Repository of the University of Ljubljana (University of Ljubljana) (publishedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: oxidative stress, reactive oxygen species, antioxidants, synthetic antioxidants, stress response, pathogen defense, systemic signaling, aging, cancer, oxidative damage
MeSH terms: Animals, Antioxidants, Clinical Trials as Topic, Gene Expression Regulation, Humans, Neoplasms, Reactive Oxygen Species, Oxidative Stress

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