The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Functional Roles of Fatty Acids and Their Effects on Human Health
Abstract
A variety of fatty acids exists in the diet of humans, in the bloodstream of humans, and in cells and tissues of humans. Fatty acids are energy sources and membrane constituents. They have biological activities that act to influence cell and tissue metabolism, function, and responsiveness to hormonal and other signals. The biological activities may be grouped as regulation of membrane structure and function; regulation of intracellular signaling pathways, transcription factor activity, and gene expression; and regulation of the production of bioactive lipid mediators. Through these effects, fatty acids influence health, well‐being, and disease risk. The effects of saturated, cis monounsaturated, ω‐6 and ω‐3 polyunsaturated, and trans fatty acids are discussed. Although traditionally most interest in the health impact of fatty acids related to cardiovascular disease, it is now clear that fatty acids influence a range of other diseases, including metabolic diseases such as type 2 diabetes, inflammatory diseases, and cancer. Scientists, regulators, and communicators have described the biological effects and the health impacts of fatty acids according to fatty acid class. However, it is now obvious that within any fatty acid class, different members have different actions and effects. Thus, it would seem more appropriate to describe biological effects and health impacts of individual named fatty acids, although it is recognized that this would be a challenge when communicating outside of an academic environment (eg, to consumers).
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1 retracted
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Self-citationEffect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
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Cited by
Djuricic, I., & Calder, P. C. (2021) · Nutrients · doi:10.3390/nu13072421 · Cited by 1,015
Self-citationHixson, S. M., & Arts, M. T. (2016) · Global Change Biology · doi:10.1111/gcb.13295 · Cited by 317
Machate, D. J., Figueiredo, P. S., Marcelino, G., Guimarães, R. D. C. A., Hiane, P. A., Bogo, D., Pinheiro, V. A. Z., Oliveira, L. C. S. D., & Pott, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114093 · Cited by 243
The lauric acid-activated signaling prompts apoptosis in cancer cells
Lappano, R., Sebastiani, A., Cirillo, F., Rigiracciolo, D. C., Galli, G. R., Curcio, R., Malaguarnera, R., Belfiore, A., Cappello, A. R., & Maggiolini, M. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.63 · Cited by 169
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group
Calder, P. C., Adolph, M., Deutz, N. E., Grau, T., Innes, J. K., Klek, S., Lev, S., Mayer, K., Michael-Titus, A. T., Pradelli, L., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.08.032 · Cited by 158
Self-citation
Metadata
- Authors
- Calder, P. C.
- Venue
- Journal of Parenteral and Enteral Nutrition
- Publisher
- Wiley
- Published
- 2015-07-15
- Volume
- 39
- Issue
- 1S
- Pages
- 18S-32S
- ISSN
- 0148-6071 (ISSN-L)
- 1941-2444
- OpenAlex
- W2144891204
- Cited by
- 1,160
- References
- 178
- FWCI
- 45.31
- Type
- journal article
- Language
- en
- Open access
- closed
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