CoChat
Sign Up
Cited by 194Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentBurn Injury Management and Outcomes

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Oral Glutamine Decreases Bacterial Translocation and Improves Survival in Experimental Gut‐Origin Sepsis

Gianotti, Luca, Alexander, J. Wesley, Gennari, Roberto, Pyles, Tonyia, Babcock, George F.·1995·Journal of Parenteral and Enteral Nutrition
DOI 10.1177/014860719501900169
Open this paper in CoChat — free account

Abstract

Background: Glutamine has been shown to be an important dietary component for the maintenance of gut metabolism. The purpose of this study was to assess the potential benefit of glutamine‐enriched diets on experimental gut‐derived sepsis. Methods: BALB/c mice were fed either 2% glutamine‐supplemented or 1% glycine‐supplemented (near‐isonitrogenous control) AIN‐76A diets. Control mice received either nonsupplemented AIN‐76A or regular Purina Rodent Laboratory Mouse Chow 5001 diets. After 10 days of feeding, the mice were transfused with allogeneic blood (from C3H/HeJ mice), and the feeding protocols were continued for an additional 5 days. The mice then underwent gavage with 10 10 Escherichia coli labeled with either indium‐111 oxine or [14 C]glucose followed immediately by a 20% burn injury. Some mice were observed 10 days postburn for survival rates. Others were killed 4 hours after burn, and the mesenteric lymph nodes, liver, and spleen were harvested to determine radionuclide and bacterial colony counts. The percentages of viable translocated E coli were also calculated. Results: Mice fed glutamine‐enriched diets had a lower degree of translocation (as measured by both radionuclide and bacterial counts) to the tissues than did the other groups and had an improvement in the ability to kill translocated E coli (as measured by the percentage of viable bacteria). Survival was significantly higher in the group fed 2% glutamine (81%) compared with the groups fed 1% glycine (36%), AIN‐76A (35%), and Purina Rodent Laboratory Mouse Chow 5001 (36%) diets (p <.004). Conclusions: Glutamine‐supplemented enteral diets may exert important benefits in preventing gut‐origin sepsis after trauma (Journal of Parenteral and Enteral Nutrition 19:69–74, 1995)

Overview

Integrity signals

Registry

Crossref · 10.1177/014860719501900169

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Gianotti L., 1993, Prostaglandin E, analogues misoprostal and enisoprost decrease microbial transolocation and modulate the immune response, Circ Shock, 40, 243

Cited by

Sorted by citations

See all 194

Related

See all

Metadata

Authors
Gianotti, L., Alexander, J. W., Gennari, R., Pyles, T., & Babcock, G. F.
Affiliations
  • University of Milan (IT)
  • University of Cincinnati (US)
ORCID
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
1995-01
Volume
19
Issue
1
Pages
69-74
ISSN
  • 0148-6071 (ISSN-L)
  • 1941-2444
DOI
10.1177/014860719501900169
OpenAlex
W2027495250
Cited by
194
References
29
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 4
FWCI
12.84
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Parenteral and Enteral Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Funders
  • National Institutes of Health (5r01ai012936-20)
  • National Institute of Allergy and Infectious Diseases (AI12936)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
Keywords
glutamine supplementation, bacterial translocation, Escherichia coli, burns, enteral nutrition, glycine, survival, mesenteric lymph nodes
MeSH terms
Animals, Burns, Enteral Nutrition, Escherichia coli, Escherichia coli Infections, Female, Glutamine, Indium Radioisotopes, Liver, Lymph Nodes, Mice, Inbred BALB C, Mice, Inbred C3H, Spleen, Colony Count, Microbial, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review