Cited by 194Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentBurn Injury Management and Outcomes

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Oral Glutamine Decreases Bacterial Translocation and Improves Survival in Experimental Gut‐Origin Sepsis

Gianotti, Luca, Alexander, J. Wesley, Gennari, Roberto, Pyles, Tonyia, Babcock, George F.·1995·Journal of Parenteral and Enteral Nutrition

DOI 10.1177/014860719501900169

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Abstract

Background: Glutamine has been shown to be an important dietary component for the maintenance of gut metabolism. The purpose of this study was to assess the potential benefit of glutamine‐enriched diets on experimental gut‐derived sepsis. Methods: BALB/c mice were fed either 2% glutamine‐supplemented or 1% glycine‐supplemented (near‐isonitrogenous control) AIN‐76A diets. Control mice received either nonsupplemented AIN‐76A or regular Purina Rodent Laboratory Mouse Chow 5001 diets. After 10 days of feeding, the mice were transfused with allogeneic blood (from C3H/HeJ mice), and the feeding protocols were continued for an additional 5 days. The mice then underwent gavage with 10 10 Escherichia coli labeled with either indium‐111 oxine or [14 C]glucose followed immediately by a 20% burn injury. Some mice were observed 10 days postburn for survival rates. Others were killed 4 hours after burn, and the mesenteric lymph nodes, liver, and spleen were harvested to determine radionuclide and bacterial colony counts. The percentages of viable translocated E coli were also calculated. Results: Mice fed glutamine‐enriched diets had a lower degree of translocation (as measured by both radionuclide and bacterial counts) to the tissues than did the other groups and had an improvement in the ability to kill translocated E coli (as measured by the percentage of viable bacteria). Survival was significantly higher in the group fed 2% glutamine (81%) compared with the groups fed 1% glycine (36%), AIN‐76A (35%), and Purina Rodent Laboratory Mouse Chow 5001 (36%) diets (p <.004). Conclusions: Glutamine‐supplemented enteral diets may exert important benefits in preventing gut‐origin sepsis after trauma (Journal of Parenteral and Enteral Nutrition 19:69–74, 1995)

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Authors: Gianotti, L., Alexander, J. W., Gennari, R., Pyles, T., & Babcock, G. F.
Affiliations: University of Milan (IT)
University of Cincinnati (US)
ORCID: Gianotti, Luca
Gennari, Roberto
Venue: Journal of Parenteral and Enteral Nutrition
Publisher: Wiley
Published: 1995-01
Volume: 19
Issue: 1
Pages: 69-74
ISSN: 0148-6071 (ISSN-L)
1941-2444
DOI: 10.1177/014860719501900169
OpenAlex: W2027495250
Cited by: 194
References: 29
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 13 · 2013: 5 · 2012: 4
FWCI: 12.84
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Parenteral and Enteral Nutrition (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Funders: National Institutes of Health (5r01ai012936-20)
National Institute of Allergy and Infectious Diseases (AI12936)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
Keywords: glutamine supplementation, bacterial translocation, Escherichia coli, burns, enteral nutrition, glycine, survival, mesenteric lymph nodes
MeSH terms: Animals, Burns, Enteral Nutrition, Escherichia coli, Escherichia coli Infections, Female, Glutamine, Indium Radioisotopes, Liver, Lymph Nodes, Mice, Inbred BALB C, Mice, Inbred C3H, Spleen, Colony Count, Microbial, Mice

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Oral Glutamine Decreases Bacterial Translocation and Improves Survival in Experimental Gut‐Origin Sepsis

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