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Cited by 13Carcinogens and Genotoxicity AssessmentWater Treatment and DisinfectionImmunotoxicology and immune responses

Tumor induction by concurrent oral administration of ethylenethiourea and sodium nitrite in mice

Yoshida, Akiyoshi, Harada, Takanori, Maita, Keizo·1993·Toxicologic Pathology
DOI 10.1177/019262339302100306
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Abstract

Carcinogenic potential of ethylenethiourea (ETU) in combination with sodium nitrite was investigated in ICR mice of both sexes. Groups of 30 males and 30 females each were given 10 weekly oral administrations of ETU and sodium nitrite with the following combinations of dosing (ETU vs sodium nitrite, mg/kg/wk): 0 vs 0, 100 vs 0, 0 vs 70, 25 vs 17.5, 50 vs 35, and 100 vs 70. Thereafter, the animals were allowed to live without treatment up to 18 mo after the first administration. Concurrent administration of ETU and sodium nitrite caused earlier development of tumors and/or dose-dependent increases in the incidences of tumors in the lymphatic tissue, lung, forestomach, Harderian gland, and uterus, whereas treatment with either ETU or sodium nitrite failed to show carcinogenic activity. In addition, carcinomas in the forestomach and uterine horn were limited to mice receiving concurrent administrations of ETU and sodium nitrite. These results indicate that ETU is most probably converted in vivo into N-nitroso ETU and that the N-nitroso ETU has a greater carcinogenic potential in mice than ETU alone.

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Crossref · 10.1177/019262339302100306

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  • Early studies suggested continuous feeding of high milligram doses of sodium nitrite could facilitate the development of tumors.

    “Early studies suggested that continuous feeding of high milligram doses of sodium nitrite could facilitate the development of tumors [269–271].”

    From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [271]

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Authors
Yoshida, A., Harada, T., & Maita, K.
Affiliations
The Institute of Environmental Toxicology (JP)
Venue
Toxicologic Pathology
Publisher
SAGE Publications
Published
1993-04
Volume
21
Issue
3
Pages
303-310
ISSN
  • 0192-6233 (ISSN-L)
  • 1533-1601
DOI
10.1177/019262339302100306
OpenAlex
W2138772541
Cited by
13
References
21
Citations by year
2022: 1 · 2021: 1 · 2020: 2 · 2012: 1
FWCI
0.59
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Toxicologic Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
ethylenethiourea, sodium nitrite, tumor induction, carcinogenicity, N-nitroso compounds, forestomach carcinoma, uterine carcinoma, lymphoma, lung cancer, ICR mice, food carcinogens
MeSH terms
Animals, Biotransformation, Carcinogens, Cocarcinogenesis, Ethylenethiourea, Female, Male, Mice, Inbred ICR, Neoplasms, Experimental, Sodium Nitrite, Mice

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