The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Role of terminal warm blood cardioplegia in complex congenital heart surgery
Abstract
Introduction Myocardial protection is vital to ensure successful open heart surgery. Cardioplegic solution is one method to achieve good myocardial protection. Inevitably, ischemia-reperfusion injury occurs with aortic crossclamping. Histidine-tryptophan-ketoglutarate solution is a frequently used cardioplegia for complex congenital heart surgery. We postulated that addition of terminal warm blood cardioplegia before removal of the aortic crossclamp might improve myocardial protection. Method A randomized controlled trial was conducted on 109 cyanotic patients aged, 1 to 5 years who underwent complex biventricular repair. They were divided into a control group of 55 patients who had histidine-tryptophan-ketoglutarate only and a treatment group of 54 who had histidine-tryptophan-ketoglutarate with terminal warm blood cardioplegia. Endpoints were clinical parameters, troponin I levels, and caspase-3 as an apoptosis marker. Results The incidence of low cardiac output syndrome was 34%, with no significant difference between groups (35.2% vs. 33.3%, p = 0.84). The incidence of arrhythmias in our treatment group was lower compared to the control group (36% vs. 12%, p = 0.005). Troponin I and caspase-3 results did not show any significant differences between groups. For cases with Aristotle score ≥ 10, weak expression of caspase-3 in the treatment group post-cardiopulmonary bypass was lower compared to the control group. Conclusion For complex congenital cardiac surgery, the addition of terminal warm blood cardioplegia does not significantly improve postoperative clinical or metabolic markers.
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“In the pediatric population reported incidences are between 17 and 67% (9–11).”
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Enhancement of myocardial recovery with terminal ‘hot shot’ cardioplegia
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Metadata
- Authors
- Busro, P. W., Romolo, H., Sastroasmoro, S., Rachmat, J., Sadikin, M., Santoso, A., Boom, C. E., Suwarto, S., & Jusuf, A. A.
- Affiliations
- Pembuluh Darah Harapan Kita (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- University of Indonesia (ID)
- Corresponding author
- Busro, Pribadi Wiranda
- ORCID
- Venue
- Asian Cardiovascular and Thoracic Annals
- Publisher
- SAGE Publications
- Published
- 2018-02-15
- Volume
- 26
- Issue
- 3
- Pages
- 196-202
- ISSN
- 0218-4923 (ISSN-L)
- 1816-5370
- OpenAlex
- W2789672860
- Cited by
- 6
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asian Cardiovascular and Thoracic Annals (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Keywords
- histidine-tryptophan-ketoglutarate, cardioprotection, congenital heart surgery, cyanotic congenital heart disease, biventricular repair, aortic cross-clamping, ischemia-reperfusion injury, low cardiac output syndrome, postoperative arrhythmia, troponin I, caspase-3, apoptosis
- MeSH terms
- Arrhythmias, Cardiac, Cardiac Output, Low, Cardioplegic Solutions, Child, Preschool, Female, Glucose, Heart Arrest, Induced, Heart Defects, Congenital, Humans, Indonesia, Infant, Male, Mannitol, Myocardium, Potassium Chloride, Procaine, Temperature, Time Factors, Biomarkers, Treatment Outcome, Apoptosis, Troponin I, Caspase 3
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- CoChat. (2026). Citation check: Role of terminal warm blood cardioplegia in complex congenital heart surgery. https://app.cochat.ai/papers/10.1177/0218492318759105
- The paper
- Busro, P. W., Romolo, H., Sastroasmoro, S., Rachmat, J., Sadikin, M., Santoso, A., Boom, C. E., Suwarto, S., & Jusuf, A. A. (2018). Role of terminal warm blood cardioplegia in complex congenital heart surgery. Asian Cardiovascular and Thoracic Annals. https://doi.org/10.1177/0218492318759105
