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Cited by 27Palliative Care and End-of-Life IssuesHead and Neck Cancer StudiesPalliative and Oncologic Care

Disease trajectories, place and mode of death in people with head and neck cancer: Findings from the ‘Head and Neck 5000’ population-based prospective clinical cohort study

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Mayland, Catriona R, Ingarfield, Kate, Rogers, Simon N, Dey, Paola, Thomas, Steven, Waylen, Andrea, Leary, Sam D, Pring, Miranda +4 more·2020·Palliative Medicine
DOI 10.1177/0269216320904313PMC PMC7238508
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Abstract

Background: Few large studies describe initial disease trajectories and subsequent mortality in people with head and neck cancer. This is a necessary first step to identify the need for palliative care and associated services. Aim: To analyse data from the Head and Neck 5000 study to present mortality, place and mode of death within 12 months of diagnosis. Design: Prospective cohort study. Participants: In total, 5402 people with a new diagnosis of head and neck cancer were recruited from 76 cancer centres in the United Kingdom between April 2011 and December 2014. Results: Initially, 161/5402 (3%) and 5241/5402 (97%) of participants were treated with ‘non-curative’ and ‘curative’ intent, respectively. Within 12 months, 109/161 (68%) in the ‘non-curative’ group died compared with 482/5241 (9%) in the ‘curative’ group. Catastrophic bleed was the terminal event for 10.4% and 9.8% of people in ‘non-curative’ and ‘curative’ groups, respectively; terminal airway obstruction was recorded for 7.5% and 6.3% of people in the same corresponding groups. Similar proportions of people in both groups died in a hospice (22.9% ‘non-curative’; 23.5% ‘curative’) and 45.7% of the ‘curative’ group died in hospital. Conclusion: In addition to those with incurable head and neck cancer, there is a small but significant ‘curative’ subgroup of people who may have palliative needs shortly following diagnosis. Given the high mortality, risk of acute catastrophic event and frequent hospital death, clarifying the level and timing of palliative care services engagement would help provide assurance as to whether palliative care needs are being met.

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  • Poor QoL is associated with a higher risk of mortality in HNC patients [55-57].

    “Since poor QoL is associated with a higher risk of mortality in HNC patients [55–57], and psychological interventions targeting body image distress and pain have shown their effectiveness [58], focusing on these dimensions before HNC treatment might be crucial for improving patients’ overall QoL and survival rates.”

    From Psychological variables associated with quality of life in patients with head and neck cancer: the role of body image distress (2022) · cites this paper as [57]

    The Results (Overall survival results; page unavailable) associate poorer WHO performance status with higher mortality, but WHO performance status is not a quality-of-life measure in this analysis. Searches for quality of life as a predictor of mortality or survival found no passage establishing the claimed association in head and neck cancer patients. (LLM, conf=0.76)

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Research works printed but not linked: 1

  1. [7]Mayland CR Payne S. Head and neck cancer: a marginalised group? Pall Med 2018; 32(8): 1286– 1287. 30095385

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Authors
Mayland, C. R., Ingarfield, K., Rogers, S. N., Dey, P., Thomas, S., Waylen, A., Leary, S. D., Pring, M., Hurley, K., Waterboer, T., Pawlita, M., & Ness, A. R.
Affiliations
  • University of Liverpool (GB)
  • University Hospitals Bristol NHS Foundation Trust (GB)
  • Edge Hill University (GB)
  • University of Bristol (GB)
  • German Cancer Research Center (DE)
Corresponding author
Mayland, Catriona R
ORCID
Venue
Palliative Medicine
Publisher
SAGE Publications
Published
2020-02-27
Volume
34
Issue
5
Pages
639-650
ISSN
  • 0269-2163 (ISSN-L)
  • 1477-030X
DOI
10.1177/0269216320904313
PMC
PMC7238508
OpenAlex
W2998755117
Cited by
27
References
45
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5
FWCI
2.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Palliative Medicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Edge Hill University Research Information Repository (Edge Hill University) (publishedVersion, cc-by-nc-nd)
  • Bristol Research (University of Bristol) (publishedVersion, cc-by)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • Explore Bristol Research (submittedVersion, cc-by)
Funders
  • Cancer Research UK (C18281/, C18281 / A19169, A19169, 25350, 15954)
  • National Institute for Health and Care Research (C18281/A19169, RP-PG-0707-10034)
  • Programme Grants for Applied Research (RP-PG-0707-10034)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
  • Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative and Oncologic Care
Keywords
head and neck cancer, disease trajectories, mortality, place of death, mode of death, palliative care needs, curative treatment, non-curative treatment, hospice deaths, in-hospital mortality
MeSH terms
Aged, Female, United Kingdom, Head and Neck Neoplasms, Humans, Male, Middle Aged, Palliative Care, Prospective Studies

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