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Cited by 17Sleep and related disordersTreatment of Major DepressionHeart Rate Variability and Autonomic Control

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Effects of Reboxetine on Sleep and Nocturnal Cardiac Autonomic Activity in Patients with Dysthymia

Ferini-Strambi, Luigi, Manconi, Mauro, Castronovo, Vincenza, Riva, Laura, Bianchi, Anna·2004·Journal of Psychopharmacology
DOI 10.1177/026988110401800313
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Abstract

Antidepressants may have sleep and autonomic side-effects. The acute and long-term effect of reboxetine (2 mg b.i.d.) on sleep and cardiac autonomic activity was compared with that of placebo in a single-blind study. Twelve patients affected by dysthymia underwent four polysomnographic studies at baseline (placebo); at night 3 (reboxetine; acute effect); at night 9 (reboxetine; intermediate-term effect); and at night 122 (reboxetine; chronic effect). After the first administration, reboxetine increased time awake after sleep onset, number of awakenings, percentage of stages 1 and 2 non-rapid eye movement (REM), and reduced the amount of stages 3–4 non-REM, but all these effects disappeared by continuing treatment. However, reboxetine caused a persistent suppression of REM sleep, which was accompanied by an increase of REM sleep latency. The spectral analysis of heart ratevariability showed a trend towards an increase in sympathetic activity with both acute and intermediate reboxetine use. Long-term treatment with 4 mg reboxetine does not cause significant changes in cardiac autonomic function.

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Crossref · 10.1177/026988110401800313

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  • One uncontrolled study showed evidence of transient sleep disruption, but persistent REM suppression, with 2mg (b.d.) of reboxetine in 12 dysthymic patients.

    “No RCTs were found in the systematic review, but one uncontrolled study showed evidence of transient sleep disruption, but persistent REM suppression, with 2mg (b.d.) of reboxetine in 12 dysthymic patients (Ferini-Strambi et al., 2004), and (Kuenzel et al., 2004) found nocturnal disturbance and reduced sleep efficiency with reboxetine (8-10mg) in 8 depressed patients.”

    From Antidepressants and their effect on sleep (2005) · cites this paper as Ferini-Strambi et al., 2004

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Metadata

Authors
Ferini-Strambi, L., Manconi, M., Castronovo, V., Riva, L., & Bianchi, A.
Affiliations
  • Sleep Disorders Center, Università Vita-Salute, IRCCS H San Raffaele, Italy
  • Vita-Salute San Raffaele University (IT)
  • Politecnico di Milano (IT)
ORCID
Venue
Journal of Psychopharmacology
Publisher
SAGE Publications
Published
2004-09
Volume
18
Issue
3
Pages
417-422
ISSN
  • 0269-8811 (ISSN-L)
  • 1461-7285
DOI
10.1177/026988110401800313
OpenAlex
W2063913201
Cited by
17
References
1
Citations by year
2026: 1 · 2022: 1 · 2021: 2 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Virtual Community of Pathological Anatomy (University of Castilla La Mancha) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
reboxetine, dysthymia, sleep, REM sleep suppression, REM latency, cardiac autonomic function, heart rate variability, sympathetic activity, antidepressant side effects, polysomnography, long-term treatment
MeSH terms
Reboxetine, Adult, Antidepressive Agents, Autonomic Nervous System, Circadian Rhythm, Female, Heart, Humans, Male, Middle Aged, Morpholines, Sleep Stages, Wakefulness, Single-Blind Method, Adrenergic Uptake Inhibitors, Dysthymic Disorder

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