The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients
Open accessAbstract
It has frequently been demonstrated that acute tryptophan depletion (ATD) induces a transient depressed mood in some patients who are in remission from depression. However, the effects of ATD on cognitive processes in remitted depressed patients have not been investigated. The aim of the present study was to investigate the effects of different extents of depletion on mood and cognitive tasks involving neutral and emotional stimuli. Twenty patients in remission or in partial remission from depression received ATD in a double-blind, crossover design. Mood was assessed at both sessions before, at +6.5 h and +24 h afterdepletion. Cognitive assessment in both sessions started at +4.75 h, and also before and after the whole procedure. The ATD mixtures induced the expected reductions of plasma tryptophan levels. High-dose ATD induced a depressive response in a subsample of patients and impaired theprocessing of positive information independent of mood change. Attention for neutral stimuli (Stroop interference) improved in a dose-dependent manner. ATD may affect mood and cognition via different pathways: one implicated in mood regulation and the processing ofemotional information, and one for the processing of neutral information. The first pathway may be more important for discriminating vulnerability to impaired serotonin function. The comparison of the effects of high-dose and low-dose ATD is useful for those studies aiming to investigate the relationships among 5-HT, mood and cognition.
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- Authors
- Booij, L., Van der Does, A. J. W., Haffmans, P. M. J., Riedel, W. J., Fekkes, D., & Blom, M. J. B.
- Affiliations
- Leiden University (NL)
- Department of Psychology, Leiden University and Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
- Parnassia Groep (NL)
- University of Cambridge (GB)
- Erasmus MC (NL)
- Psychomedical Center Parnassia, The Hague, The Netherlands
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2005-05
- Volume
- 19
- Issue
- 3
- Pages
- 267-275
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2058087319
- Cited by
- 105
- References
- 8
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Stichting tot Steun Vereniging tot Christelijke Verzorging van Geestes- en Zenuwzieken
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- tryptophan depletion, acute tryptophan depletion, remitted depression, partial remission, mood, cognitive function, emotional processing, Stroop interference, attention, serotonin, dose-dependent effects, plasma tryptophan
- MeSH terms
- Adolescent, Adult, Affect, Aged, Cognition, Depressive Disorder, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Psychiatric Status Rating Scales, Psychomotor Performance, Reaction Time, Tryptophan, Cross-Over Studies
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