The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Review: Glutamate and dopamine dysregulation in schizophrenia — a synthesis and selective review
Abstract
The dopamine hypothesis of schizophrenia is the principal explanatory model of antipsychotic drug action. Recent discoveries extend our understanding of the neurochemistry of schizophrenia, with increasing evidence of dysfunction in glutamate and GABA as well as dopamine systems. In this review, we study the evidence for dopaminergic dysfunction in schizophrenia, drawing data from neurochemical imaging studies. We also review the NMDA receptor hypofunction hypothesis of schizophrenia as a supplementary explanatory model for the illness. We examine predictions made by the NMDA receptor hypofunction hypothesis and consider how they fit with current neurochemical findings in patients and animal models. We consider the case for glutamatergic excitotoxicity as a key process in the development and progression of schizophrenia, and suggest ways in which glutamate and dopamine dysregulation may interact in the condition.
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Cites
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Cited by
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Howes, O., McCutcheon, R., & Stone, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114563634 · Cited by 702
Self-citationStress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia
Walker, E., Mittal, V., & Tessner, K. (2008) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.4.022007.141248 · Cited by 615
Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal
Iizuka, T., Sakai, F., Ide, T., Monzen, T., Yoshii, S., Iigaya, M., Suzuki, K., Lynch, D. R., Suzuki, N., Hata, T., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000278388.90370.c3 · Cited by 517
Brain Circuits for the Internal Monitoring of Movements
Sommer, M. A., & Wurtz, R. H. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125627 · Cited by 508
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
Metadata
- Authors
- Stone, J. M., Morrison, P. D., & Pilowsky, L. S.
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2007-06
- Volume
- 21
- Issue
- 4
- Pages
- 440-452
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2145731152
- Cited by
- 348
- References
- 24
- FWCI
- 21.29
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
