Anxious versus non-anxious depression: difference in treatment outcome
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Some atypical agents may have an unfavorable side-effect profile, limiting their use in depressed patients with comorbid anxiety as they may suffer from greater side-effects.
“Some of the atypical agents may have an unfavorable side-effect profile [52], limiting its use in depressed patients with comorbid anxiety as they may suffer from greater side-effects [14].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [14]
Patients with dimensionally defined anxious depression did respond to traditional antidepressants, but were unable to maintain response or remission and suffered from greater frequency of side-effects than patients with nonanxious depression.
“A previous, large review [14] showed that patients with dimensionally defined anxious depression did respond to traditional antidepressants, but that they were unable to maintain response or remission and suffered from greater frequency of side-effects than patients with nonanxious depression [14].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [14]
The neural architecture of blame-related feelings differs between non-anxious and anxious forms of major depressive disorder, the latter being predominant in populations with treatment-resistant depression.
“This is in keeping with the hypothesis that the neural architecture of blame-related feelings differs between non-anxious and anxious forms of MDD, the latter being predominant in populations with treatment-resistant depression ( Dold et al., 2017 , Domschke et al., 2010 , Gaspersz et al., 2017 ).”
From Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder (2023) · cites this paper as Domschke et al., 2010
Co-morbidities themselves can contribute to clinical outcomes, which is particularly evident with the reported association between co-morbid anxiety disorders in major depressive disorder and poorer clinical outcomes.
“Moreover, co-morbidities themselves can contribute to clinical outcomes, which is particularly evident with the reported association between co-morbid anxiety disorders in MDD and poorer clinical outcomes ( Dold et al., 2017 , Domschke et al., 2010 , Fava et al., 2008 ).”
From Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder (2023) · cites this paper as Domschke et al., 2010
Patients with anxious major depressive disorder did not benefit from neurofeedback.
“Notably, patients with anxious MDD, commonly encountered in treatment-resistant and chronic MDD populations and which is associated with a poor prognosis ( Dold et al., 2017 , Domschke et al., 2010 , Fava et al., 2008 , Gaspersz et al., 2017 ), did not benefit from neurofeedback ( Jaeckle et al., 2021 ).”
From Self-blame-selective hyper-connectivity between anterior temporal and subgenual cortices predicts prognosis in major depressive disorder (2023) · cites this paper as Domschke et al., 2010
Cites
Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., Biggs, M. M., Zisook, S., Leuchter, A., Howland, R., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111868 · Cited by 927 · see citing works
Association of the COMT val158met Variant with Antidepressant Treatment Response in Major Depression
Baune, B. T., Hohoff, C., Berger, K., Neumann, A., Mortensen, S., Roehrs, T., Deckert, J., Arolt, V., & Domschke, K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301462 · Cited by 145 · see citing works
Self-citationPsychosocial and clinical predictors of response to pharmacotherapy for depression
Bagby, R. M., Ryder, A. G., & Cristi, C. (2002) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0243 · Cited by 115 · see citing works
Comorbidity and depression treatment
Krishnan, K. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01787-0 · Cited by 58 · see citing works
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Gaspersz, R., Nawijn, L., Lamers, F., & Penninx, B. W. J. H. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000376 · Cited by 139 · see citing works
Gaspersz, R., Lamers, F., Kent, J. M., Beekman, A. T. F., Smit, J. H., van Hemert, A. M., Schoevers, R. A., & Penninx, B. W. J. H. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.018 · Cited by 88 · see citing works
Wu, Z., Chen, J., Yuan, C., Hong, W., Peng, D., Zhang, C., Cao, L., & Fang, Y. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.03.012 · Cited by 77 · see citing works
Richards, E. M., Mathews, D. C., Luckenbaugh, D. A., Ionescu, D. F., Machado-Vieira, R., Niciu, M. J., Duncan, W. C., Nolan, N. M., Franco-Chaves, J. A., Hudzik, T., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4195-4 · Cited by 76 · see citing works
Pharmacologic Treatment of Dimensional Anxious Depression: A Review
Ionescu, D. F., Niciu, M. J., Richards, E. M., & Zarate, C. A. (2014) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.13r01621 · Cited by 56 · see citing works
Jiang, K., Li, L., Xueyi, W., Fang, M., Shi, J., Cao, Q., He, J., Wang, J., Tan, W., & Hu, C. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s120190 · Cited by 18 · see citing works
Fennema, D., Barker, G. J., O'Daly, O., Duan, S., Carr, E., Goldsmith, K., Young, A. H., Moll, J., & Zahn, R. (2023) · NeuroImage: Clinical · doi:10.1016/j.nicl.2023.103453 · Cited by 7 · see citing works
“This is in keeping with the hypothesis that the neural architecture of blame-related feelings differs between non-anxious and anxious forms of MDD, the latter being predominant in populations with treatment-resistant depression (Dold et al., 2017; Domschke et al., 2010; Gaspersz et al., 2017b).”
BackgroundResult
- Authors
- Domschke, K., Deckert, J., Arolt, V., & Baune, B.
- Affiliations
- University of Münster (DE)
- University of Würzburg (DE)
- Department of Psychiatry, James Cook University, Queensland, Australia
- Corresponding author
- Domschke, K.
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2008-10-06
- Volume
- 24
- Issue
- 4
- Pages
- 621-622
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2071651285
- Cited by
- 42
- References
- 4
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- anxious depression, treatment outcomes, depression, anxiety comorbidity, antidepressant response
- MeSH terms
- Antidepressive Agents, Anxiety, Major Depressive Disorder, Depressive Disorder, Major, Humans, Inpatients, Middle Aged, Psychiatric Status Rating Scales, Time Factors, Treatment Outcome
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