Risperidone long-acting injectable in the treatment of treatment-resistant schizophrenia with dopamine supersensitivity psychosis: Results of a 2-year prospective study, including an additional 1-year follow-up
Abstract
Dopamine supersensitivity psychosis (DSP) resulting from antipsychotic treatment is related to treatment-resistant schizophrenia (TRS), and its treatment has not been established to date. Maintaining thoroughly stable occupancy of the dopamine D2 receptor by risperidone long-acting injectable (RLAI) is one strategy for treatment. In this study, RLAI was given as an adjunctive medication to oral antipsychotic(s), which were switched partially and gradually to RLAI in 108 treatment-resistant patients for an additional 1-year follow-up in a 2-year study, and to compare the effects in 72 patients with a DSP history (DSP group) and 36 patients without this history (NonDSP group). Although both groups showed significant improvements in the total Brief Psychotic Rating Scale (BPRS) score during the follow-up period, greater improvement was observed for the DSP group than the NonDSP group. High doses (> 850 mg chlorpromazine-dose combined of oral antipsychotics and RLAI) did not significantly change in both groups throughout the study period; however, extrapyramidal symptoms, including tardive dyskinesia, were significantly improved only in the patients with DSP. This study strongly suggested that the RLAI treatment, even with only partial switching, provides relief from refractory symptoms, particularly for patients with a history of DSP. Clinical trial registration: http://www.umin.ac.jp/:UMIN000008487
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New acute withdrawal symptoms after ketamine discontinuation have been described: craving, dysphoria, shaking, sweating, palpitations, tiredness, low appetite, low mood, chills, autonomic arousal, lacrimation, restlessness, anxiety, nightmares, paranoia, delusions, and hallucinations.
“New acute withdrawal symptoms after ketamine discontinuation have been described. They are craving, dysphoria, shaking, sweating, palpitations, tiredness, low appetite, low mood, chills, autonomic arousal, lacrimation, restlessness, anxiety, nightmares, paranoia, delusions, and hallucinations [145-147].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [147]
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- Authors
- Kimura, H., Kanahara, N., Sasaki, T., Komatsu, N., Ishige, M., Muneoka, K., Ino, H., Yoshimura, K., Yamanaka, H., Suzuki, T., Komatsu, H., Watanabe, H., Shimizu, E., & Iyo, M.
- Affiliations
- Chiba University (JP)
- Chiba Hospital (JP)
- Sodegaura Satsukidai Hospital (JP)
- Department of Psychiatry, Gakuji-kai Kimura Hospital, Chiba, Japan
- Department of Psychiatry, Doujin-kai Kisaradzu Hospital, Chiba, Japan
- Corresponding author
- Kanahara, Nobuhisa
- ORCID
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2016-07-01
- Volume
- 30
- Issue
- 8
- Pages
- 795-802
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2465954351
- Cited by
- 26
- References
- 28
- Citations by year
- 2023: 4 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 5
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chiba University
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- long-acting injectable risperidone, treatment-resistant schizophrenia, dopamine D2 receptor occupancy, adjunctive antipsychotic therapy, extrapyramidal symptoms, tardive dyskinesia, chlorpromazine equivalents
- MeSH terms
- Adolescent, Adult, Aged, Chlorpromazine, Delayed-Action Preparations, Dopamine, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Injections, Male, Middle Aged, Prospective Studies, Psychiatric Status Rating Scales, Psychoses, Substance-Induced, Schizophrenia, Antipsychotic Agents, Receptors, Dopamine D2, Risperidone, Young Adult
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