Effects of long-acting injectable antipsychotics versus oral antipsychotics on autonomic nervous system activity in schizophrenic patients
Open accessAbstract
Objective: Long-acting injections (LAIs) of antipsychotics show distinct pharmacokinetic profiles from oral antipsychotics (OAPs). Although there may be differences in adverse event frequency, any differences in their effects on autonomic nervous system (ANS) remain unclear. Patients and methods: In total, 270 schizophrenic patients were recruited in this study: 241 received OAPs (risperidone, olanzapine, quetiapine, or aripiprazole) and 29 received LAIs (risperidone LAI, aripiprazole LAI, or paliperidone palmitate) as monotherapy. Heart rate variability was measured as an index of ANS activity, and the low-frequency (0.03–0.15 Hz) component, high-frequency (0.15–0.40 Hz) component, and total power (0.03–0.40 Hz) were calculated. Components were compared between the groups using t-tests. Results: A significant difference was detected in the low-frequency component between the OAP and LAI groups ( P =0.046). No significant difference was found in total power or the high-frequency component between the two groups. Conclusion: Compared with OAPs, LAIs have fewer adverse effects on ANS activity, particularly the low-frequency component, as determined using a spectral analysis of heart rate variability. Keywords: long-acting injectable antipsychotics, autonomic nervous system, heart rate variability, adverse effect
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Long-acting injectable antipsychotics have fewer adverse effects on ANS activity, particularly sympathetic nervous system activity as assessed through LF-HRV, compared with oral antipsychotics.
“Lastly, the effects of APs on ANS activity may also be related to their route of administration as one study to date has provided evidence that long-acting injectable APs have fewer adverse effects on ANS activity, and particularly SNS activity (as assessed through LF-HRV), in comparison to oral APs54.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [54]
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Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
Stogios, N., Gdanski, A., Gerretsen, P., Chintoh, A. F., Graff-Guerrero, A., Rajji, T. K., Remington, G., Hahn, M. K., & Agarwal, S. M. (2021) · npj Schizophrenia · doi:10.1038/s41537-021-00151-6 · Cited by 98 · see citing works
- Authors
- Suda, A., Hattori, S., Kishida, I., Miyauchi, M., Shiraishi, Y., Fujibayashi, M., Tsujita, N., Ishii, C., Ishii, N., Moritani, T., & Hirayasu, Y.
- Affiliations
- Yokohama City University (JP)
- Setsunan University (JP)
- Kyoto University (JP)
- Kyoto Sangyo University (JP)
- Corresponding author
- Suda, Akira
- ORCID
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2018-09
- Volume
- Volume 14
- Pages
- 2361-2366
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC6149934
- OpenAlex
- W2890487346
- Cited by
- 5
- References
- 52
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Japan Society for the Promotion of Science (16K10254)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- long-acting injectable antipsychotics, oral antipsychotics, autonomic nervous system activity, heart rate variability, schizophrenia, low-frequency components, spectral analysis, risperidone, aripiprazole, paliperidone palmitate, adverse effects
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