Psychiatric hospitalization following antipsychotic medication cessation in first episode psychosis
Open accessAbstract
BACKGROUND: There are questions about the risk-benefit balance of longer-term antipsychotic medication treatment following first episode psychosis, especially in relation to relapse because of dopamine supersensitivity following treatment cessation. AIM: The purpose of this study was to determine whether hospitalization rates in first episode psychosis patients are associated with length of initial oral antipsychotic medication exposure. METHODS: We examined psychiatric hospitalization rates in patients experiencing first episode of psychosis from the total population of Sweden between 1 January 2007-31 December 2016 ( n=7043). We categorised patients by the length of first antipsychotic treatment (<6 months, 6 months to <1 year, 1 year to <2 years, 2 years to <5 years and ⩾5 years). RESULTS: Compared to those treated for <6 months, individuals receiving oral antipsychotic medications for ⩾5 years had less than half the cumulative incidence of hospitalization at all times between 1-4 years after treatment cessation. CONCLUSION: We found no evidence that hospitalization rates increased with increasing baseline antipsychotic exposure.
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- Authors
- Hayes, J. F., Osborn, D. P., Lundin, A., & Dalman, C.
- Affiliations
- University College London (GB)
- Karolinska Institutet (SE)
- Corresponding author
- Hayes, Joseph F
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2019-02-19
- Volume
- 33
- Issue
- 4
- Pages
- 532-534
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- PMC
- PMC7613091
- OpenAlex
- W2916168578
- Cited by
- 8
- References
- 8
- Citations by year
- 2026: 1 · 2025: 3 · 2021: 3 · 2020: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd (523-2010-1052)
- Wellcome Trust (211085/Z/18/Z)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Keywords
- first-episode psychosis, antipsychotic drugs, treatment discontinuation, psychiatric hospitalization, relapse, dopamine supersensitivity, cumulative incidence
- MeSH terms
- Adult, Female, Hospitalization, Hospitals, Psychiatric, Humans, Male, Psychotic Disorders, Recurrence, Registries, Sweden, Time Factors, Antipsychotic Agents, Withholding Treatment, Young Adult
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