The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression.
Abstract
The onset and reversibility of major depression is likely to be explained by diffuse neuromodulatory mechanisms rather than permanent abnormalities of connectivity and neurotransmission. However, the expression of mood state appears to involve fronto-striatal mechanisms. Lesions of the ventral frontal cortex give rise to profound modification of affect and behaviour not explained by effects on current intellectual function. These may represent the most extreme possible disturbances of emotional experience. Neuropsychological testing in major depression shows evidence of slowing in motor and cognitive domains with additional prominent effects on mnemonic function most marked in the elderly. Structural imaging with X-ray computed tomography or magnetic resonance imaging in older patients with major depression shows evidence of structural abnormality compared with controls. These findings are not highly localizing but they tend to confirm the role of cognitive impairment as an important age-related risk factor for major depression. Perfusion or metabolic imaging reflects both reversible changes in function and permanent loss of active neurones. The usual finding has been reductions in anterior brain structures in major depression. Hypoperfusion tends to be greatest in frontal, temporal and parietal areas and most extensive in older (male) patients; high Hamilton scores tend to be associated with reduced uptake. There have also been correlations in the cingulate cortex between increased perfusion and other aspects of the mental state. In general, reductions in frontal areas may be more likely in patients with impoverished mental states. The more prominent impairments of memory are likely to be associated with the finding of impaired temporal function or with a more diffuse failure of neuromodulation.
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“The impairment relative to controls grows with the difficulty of the problem; and depressed subjects also spend increasing amounts of time thinking about the harder problems, without showing improved choices [50].”
From Bonsai trees in your head: how the pavlovian system sculpts goal-directed choices by pruning decision trees (2012) · cites this paper as [50]
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Cites
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527
From Neuropsychology to Mental Structure
Shallice, T. (1988) · doi:10.1017/cbo9780511526817 · Cited by 4,072
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Alexander, G. E., Crutcher, M. D., & DeLong, M. R. (1990) · PubMed · Cited by 2,422
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
(1991) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62678-3 · Cited by 1,961
Corbetta, M., Miezin, F. M., Dobmeyer, S., Shulman, G. L., & Petersen, S. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-08-02383.1991 · Cited by 1,590
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527
The Return of Phineas Gage: Clues About the Brain from the Skull of a Famous Patient
Damásio, H., Grabowski, T. J., Frank, R. J., Galaburda, A. M., & Damásio, A. R. (1994) · Science · doi:10.1126/science.8178168 · Cited by 1,520
Borkowski, J. G., Benton, A. L., & Spreen, O. (1967) · Neuropsychologia · doi:10.1016/0028-3932(67)90015-2 · Cited by 1,324
Research works printed but not linked: 5
- Dolan R.J., 1991, J Cereb Blood Flow Metab, 67, S654
- Drevets W.C., 1992, Psychopharmac Bull, 28, 261
- Dupont R.M., 1990, Clinical and neuropsychological significance. Arch Gen Psychiat, 47, 55
- Mayberg H.S., 1994, J Nucl Med, 35, 929
- Starkstein S.E., 1995, Neuropsychiat, Neuropsychol Behav Neurol, 8, 38
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Cognitive deficits in depression: Possible implications for functional neuropathology
Austin, M.-P., Mitchell, P., & Goodwin, G. M. (2001) · British Journal of Psychiatry · doi:10.1192/bjp.178.3.200 · Cited by 1,154
Self-citationA meta-analysis of depression severity and cognitive function
McDermott, L. M., & Ebmeier, K. P. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.022 · Cited by 956
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 891
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857
Chronic stress, cognitive functioning and mental health
Marin, M.-F., Lord, C., Andrews, J., Juster, R.-P., Sindi, S., Arsenault-Lapierre, G., Fiocco, A. J., & Lupien, S. J. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.016 · Cited by 654
Metadata
- Authors
- Goodwin, G. M.
- Affiliations
- Warneford Hospital (GB)
- Corresponding author
- Goodwin, Guy M.
- ORCID
- Goodwin, Guy M.
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 1997-03
- Volume
- 11
- Issue
- 2
- Pages
- 115-122
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2141880924
- Cited by
- 199
- References
- 72
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- major depressive disorder, frontal lobe, frontostriatal circuits, cognitive impairment, memory impairment, older adults, cerebral hypoperfusion, cingulate cortex, neuromodulation, structural brain abnormalities, neuropsychological assessment, neuroimaging
- MeSH terms
- Affect, Brain Mapping, Dementia, Depressive Disorder, Energy Metabolism, Frontal Lobe, Gyrus Cinguli, Humans, Neuropsychological Tests, Regional Blood Flow, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Prefrontal Cortex
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