The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Catecholamine regulation of the prefrontal cortex
Abstract
The catecholamines dopamine (DA) and norepinephrine provide an essential modulatory influence on the working memory and attentional functions of the prefrontal cortex (PFC). The following critique reviews evidence that (1) either insufficient or excessive DA D 1 receptor stimulation is detrimental to PFC function, while DA stimulation of the D 2 family of receptors may contribute to detrimental actions in PFC and (2) that norepinephrine has an important beneficial influence on PFC function through its actions at post-synaptic, α 2A adrenergic receptors, but impairs PFC function through actions at α 1 adrenergic receptors. Critical levels of catecholamine stimulation may be needed to optimize PFC cognitive function; high levels of catecholamine release during stress may serve to take the PFC 'off-line' to allow faster, more habitual responses mediated by the posterior and/or subcortical structures to regulate behavior. These studies have relevance to our understanding and treatment of disorders with prominent symptoms of PFC dysfunction.
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Cites
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Cited by
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Decision making, the P3, and the locus coeruleus–norepinephrine system
Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.510 · Cited by 1,678
The Cognitive Neuroscience of Working Memory
D'Esposito, M., & Postle, B. R. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015031 · Cited by 1,653
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
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Metadata
- Authors
- Arnsten, A. F. T.
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 1997-03
- Volume
- 11
- Issue
- 2
- Pages
- 151-162
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2062990061
- Cited by
- 488
- References
- 118
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
