Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow
Open accessAbstract
Clearance of waste products from the brain is of vital importance. Recent publications suggest a potential clearance mechanism via paravascular channels around blood vessels. Arterial pulsations might provide the driving force for paravascular flow, but its flow pattern remains poorly characterized. In addition, the relationship between paravascular flow around leptomeningeal vessels and penetrating vessels is unclear. In this study, we determined blood flow and diameter pulsations through a thinned-skull cranial window. We observed that microspheres moved preferentially in the paravascular space of arteries rather than in the adjacent subarachnoid space or around veins. Paravascular flow was pulsatile, generated by the cardiac cycle, with net antegrade flow. Confocal imaging showed microspheres distributed along leptomeningeal arteries, while their presence along penetrating arteries was limited to few vessels. These data suggest that paravascular spaces around leptomeningeal arteries form low resistance pathways on the surface of the brain that facilitate cerebrospinal fluid flow.
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Animal studies have shown communication between the subarachnoid CSF space and perivascular compartments of the brain and spinal cord.
“Previous animal studies have shown communication between the subarachnoid cerebrospinal fluid (CSF) space and perivascular compartments of the brain (6-10) and spinal cord (11).”
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Fluid dynamics of cerebrospinal fluid flow in perivascular spaces
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- Authors
- Bedussi, B., Almasian, M., de Vos, J., VanBavel, E., & Bakker, E. N.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands
- Corresponding author
- Bakker, Erik NTP
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 2017-10-17
- Volume
- 38
- Issue
- 4
- Pages
- 719-726
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- PMC
- PMC5888857
- OpenAlex
- W2766060569
- Cited by
- 181
- References
- 5
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 18 · 2023: 24 · 2022: 26 · 2021: 31 · 2020: 19 · 2019: 16 · 2018: 11
- FWCI
- 6.16
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-02-06)
- Open access
- hybrid
- doi.org
- Locations
- Journal of Cerebral Blood Flow & Metabolism (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission
- Internationale Stichting Alzheimer Onderzoek
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- perivascular spaces, cerebrospinal fluid flow, arterial pulsation, leptomeningeal arteries, penetrating arteries, subarachnoid space, microsphere tracking, brain waste clearance, pulsatile flow, antegrade flow
- MeSH terms
- Animals, Blood Flow Velocity, Blood Volume, Brain, Cerebral Arteries, Cerebrospinal Fluid, Cerebrovascular Circulation, Intracranial Pressure, Male, Meninges, Mice, Inbred C57BL, Microspheres, Subarachnoid Space, Microscopy, Confocal, Mice
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