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Model Transparency and Validation: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force–7

Open access
Eddy, David M., Hollingworth, William, Caro, J. Jaime, Tsevat, Joel, McDonald, Kathryn M., Wong, John B.·2012·Medical Decision Making

Abstract

Trust and confidence are critical to the success of health care models. There are two main methods for achieving this: transparency (people can see how the model is built) and validation (how well it reproduces reality). This report describes recommendations for achieving transparency and validation, developed by a task force appointed by the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the Society for Medical Decision Making (SMDM). Recommendations were developed iteratively by the authors. A nontechnical description should be made available to anyone—including model type and intended applications; funding sources; structure; inputs, outputs, other components that determine function, and their relationships; data sources; validation methods and results; and limitations. Technical documentation, written in sufficient detail to enable a reader with necessary expertise to evaluate the model and potentially reproduce it, should be made available openly or under agreements that protect intellectual property, at the discretion of the modelers. Validation involves face validity (wherein experts evaluate model structure, data sources, assumptions, and results), verification or internal validity (check accuracy of coding), cross validity (comparison of results with other models analyzing same problem), external validity (comparing model results to real-world results), and predictive validity (comparing model results with prospectively observed events). The last two are the strongest form of validation. Each section of this paper contains a number of recommendations that were iterated among the authors, as well as the wider modeling task force jointly set up by the International Society for Pharmacoeconomics and Outcomes Research and the Society for Medical Decision Making.

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Citations

Cites

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Research works printed but not linked: 47

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Metadata

Authors
Eddy, D. M., Hollingworth, W., Caro, J. J., Tsevat, J., McDonald, K. M., & Wong, J. B.
Venue
Medical Decision Making
Published
2012-09
Volume
32
Issue
5
Pages
733-743
ISSN
  • 0272-989X (ISSN-L)
  • 1552-681X
OpenAlex
W2134023402
Cited by
799
References
8
FWCI
97.72
Type
journal article
Language
en
Open access
hybrid
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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CoChat. (2026). Citation check: Model Transparency and Validation: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force–7. https://app.cochat.ai/papers/10.1177/0272989x12454579
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Eddy, D. M., Hollingworth, W., Caro, J. J., Tsevat, J., McDonald, K. M., & Wong, J. B. (2012). Model Transparency and Validation: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force–7. Medical Decision Making. https://doi.org/10.1177/0272989x12454579

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.