Pathology of Neonatal Calf Diarrhea Induced by a Coronavirus-Like Agent
Open accessAbstract
Lesions induced by a bovine coronavirus-like agent were studied in gnotobiotic and colostrum-fed calves using gross, histologic and electron microscopic procedures. Lesions in gnotobiotic calves were present in the colon, mesenteric lymph nodes and in all segments of the small intestine. Calves killed 4 h after the onset of diarrhea had immunofluorescent epithelial cells on the villi of the small intestine and surface of the colon. Calves killed at 44 h had shortened intestinal villi and cuboidal epithelial cells. The villus-to-crypt ratio in the lower small intestine averaged 1.0 compared with 5.3 in a control calf. Immunofluorescent cells were present at the tips of the villi, and at the surface and in the crypts of the colon. Colostrum-fed calves that had serum-neutralizing antibody titers for the coronavirus-like agent developed diarrhea when inoculated orally with the agent. There was good correlation between histologic, immunofluorescent and electron microscopic findings.
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BCV replicates in the respiratory and enteric tracts.
“This result was consistent with observations in experimentally inoculated calves to support the fact that BCV replicates in the respiratory and enteric tracts. 12-16”
From Evaluation of concurrent shedding of bovine coronavirus via the respiratory tract and enteric route in feedlot cattle (2001) · cites this paper as [14]
Cites
Neonatal Calf Diarrhea: Propagation, Attenuation, and Characteristics of a Coronavirus-like Agent
Mebus, C. A., Stair, E. L., Rhodes, M. B., & Twiehaus, Μ. J. (1973) · American Journal of Veterinary Research · doi:10.2460/ajvr.1973.34.02.145 · Cited by 193 · see citing works
Self-citationCell culture propagation of neonatal calf diarrhea (scours) virus.
Mebus, C. A., Kono, M., Underdahl, N. R., et al. (1971) · PubMed · Cited by 183 · see citing works
Self-citationNeonatal Calf Diarrhea: Purification and Electron Microscopy of a Coronavirus-like Agent
Stair, E. L., Rhodes, M. B., White, R. G., & Mebus, C. A. (1972) · American Journal of Veterinary Research · doi:10.2460/ajvr.1972.33.06.1147 · Cited by 149 · see citing works
Self-citationCalf Diarrhea (Scours): Reproduced with a Virus from a Field Outbreak
Mebus, C. A., Underdahl, N. R., Rhodes, M. B., et al. (1969) · Lincoln (University of Nebraska) · Cited by 143 · see citing works
Self-citationPathology of Neonatal Calf Diarrhea Induced by a Reo-Like Virus
Mebus, C. A., Stair, E. L., Underdahl, N. R., et al. (1971) · Veterinary Pathology · doi:10.1177/0300985871008005-00612 · Cited by 127 · see citing works
Self-citationCharacteristics of a Coronavirus (Strain 67N) of Pigs
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Self-citationChicken Serum Proteins: A Comparison of Electrophoretic Techniques and Localization of Transferrin
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Self-citationIsolation Unit Used in Studies on Neonatal Calf Diarrhea
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Cho, K.-O., Hoet, A. E., Loerch, S. C., Wittum, T. E., & Saif, L. J. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.1436 · Cited by 88 · see citing works
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- Authors
- Mebus, C. A., Stair, E. L., Rhodes, M. B., & Twiehaus, M. J.
- Affiliations
- University of Nebraska–Lincoln (US)
- Department of Veterinary Science, University of Nebraska, Lincoln, Nebr.
- Venue
- Veterinary Pathology
- Publisher
- SAGE Publications
- Published
- 1973-01
- Volume
- 10
- Issue
- 1
- Pages
- 45-64
- ISSN
- 0300-9858 (ISSN-L)
- 1544-2217
- OpenAlex
- W2154071346
- Cited by
- 154
- References
- 10
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 10 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2012: 1
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Veterinary Pathology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Keywords
- neonatal calf diarrhea, gnotobiotic calves, colostrum feeding, villous atrophy, villus:crypt ratio, mesenteric lymph nodes, immunofluorescence, serum neutralizing antibodies, oral challenge, small intestine pathology, colon pathology
- MeSH terms
- Animals, Animals, Newborn, Cattle, Cattle Diseases, Colon, Coronaviridae, Diarrhea, Fluorescent Antibody Technique, Germ-Free Life, Intestine, Small, Lymph Nodes, Microscopy, Electron, Neutralization Tests, Virus Diseases
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