The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Effects of Applied Quadriceps and Hamstrings Muscle Loads on Forces in the Anterior and Posterior Cruciate Ligaments
Abstract
Background: Muscle contraction can subject healing knee ligament grafts to high loads. Purpose: To directly measure the effects of quadriceps and hamstrings muscle loads on forces in the anterior cruciate ligaments and posterior cruciate ligaments. Study Design: Controlled laboratory study. Methods: Thirteen cadaveric knee specimens had load cells installed to record resultant forces in both anterior and posterior cruciate ligaments under 5 loading conditions. Cruciate force measurements were repeated with a 100-N load applied to the quadriceps tendon and again with a combined 50-N biceps load and 50-N semimembranosus-semitendinosus load. Results: Applied quadriceps loads resulted in mean changes in anterior cruciate ligament and posterior cruciate ligament forces that were less than 20 N for all loading conditions. Hamstrings load significantly increased mean posterior cruciate ligament force between 30° and 105° of flexion with 100 N of applied posterior tibial force. Conclusions: At the muscle force levels used in this study, the hamstrings were more effective than the quadriceps in altering cruciate force levels, especially near 90° of flexion, where they have an excellent mechanical advantage for controlling anterior-posterior tibial translation. Clinical Relevance: Isolated hamstrings activity generally had little or no effect on anterior cruciate ligament forces but significantly increased forces in the posterior cruciate ligament beyond approximately 30° of flexion.
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“investigators have proposed a technique involving the isolation of the tibial attachment of the cruciate ligament by creating a bone plug and attaching a load sensor to measure the native ACL force in cadaveric knees [5, 6].”
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“This approach is limited to ex vivo applications.”
In the citing paper
“Another experimental study simulated active extension of the lower limb against gravity by loading the quadriceps musculature [6]. The result showed an increased load on the ACL from 0° to 45° of flexion.”
Citations
Cites
Combined knee loading states that generate high anterior cruciate ligament forces
Markolf, K. L., Burchfield, D. M., Shapiro, M. M., Shepard, M. F., Finerman, G. A. M., & Slauterbeck, J. L. (1995) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100130618 · Cited by 1,038
Self-citationMarkolf, K. L., Gorek, J. F., Kabo, J. M., & Shapiro, M. S. (1990) · The Journal of Bone & Joint Surgery · doi:10.2106/00004623-199072040-00014 · Cited by 610 · cited 2×
“Details of load cell installation and bench testing can be found in our prior publications.(10,11,14,15) A modification to this test apparatus was made that allowed application of muscle loads as the knee was passively extended under the above tibial loading conditions.”
BackgroundMethodSelf-citationLi, G., Rudy, T. W., Sakane, M., Kanamori, A., Ma, C. B., & Woo, S. L. (1999) · Journal of Biomechanics · doi:10.1016/s0021-9290(98)00181-x · Cited by 581
Anterior Cruciate Ligament Strain Behavior During Rehabilitation Exercises In Vivo
Beynnon, B. D., Fleming, B. C., Johnson, R. J., Nichols, C. E., Renström, P. A. F. H., & Pope, M. H. (1995) · The American Journal of Sports Medicine · doi:10.1177/036354659502300105 · Cited by 471
The Strain Behavior of the Anterior Cruciate Ligament During Squatting and Active Flexion-Extension
Beynnon, B. D., Johnson, R. J., Fleming, B. C., Stankewich, C. J., Renström, P. A. F. H., & Nichols, C. E. (1997) · The American Journal of Sports Medicine · doi:10.1177/036354659702500616 · Cited by 270
Direct in vitro measurement of forces in the cruciate ligaments. Part I
Wascher, D. C., Markolf, K. L., Shapiro, M. S., & Finerman, G. A. M. (1993) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199303000-00009 · Cited by 200
Self-citationIn‐vitro ligament tension pattern in the flexed knee in passive loading
Ahmed, A. M., Hyder, A., Burke, D. L., & Chan, K. H. (1987) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100050208 · Cited by 150
Markolf, K. L., Burchfield, D. M., Shapiro, M. M., Davis, B. R., Finerman, G. A. M., & Slauterbeck, J. L. (1996) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199611000-00013 · Cited by 118
Self-citationLewis, J. L., Lew, W. D., & Schmidt, J. (1982) · Journal of Biomechanical Engineering · doi:10.1115/1.3138325 · Cited by 107
A Biomechanical Study of Replacement of the Posterior Cruciate Ligament with a Graft. Part I
Markolf, K. L., Slauterbeck, J. R., Armstrong, K. L., Shapiro, M. S., & Finerman, G. A. M. (1997) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-199703000-00009 · Cited by 103
Self-citationOakes, D. A., Markolf, K. L., McWilliams, J. P., Young, C. R., & McAllister, D. R. (2002) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200206000-00007 · Cited by 86
Self-citationDesign and Performance of a Modified Buckle Transducer for the Measurement of Ligament Tension
Barry, D., & Ahmed, A. M. (1986) · Journal of Biomechanical Engineering · doi:10.1115/1.3138594 · Cited by 66
Markolf, K. L., Willems, M. J., Jackson, S. R., & Finerman, G. A. M. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160411 · Cited by 55
Self-citationHöher, J., Vogrin, T. M., Woo, S. L.-Y., Carlin, G. J., Årøen, A., & Harner, C. D. (1999) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100170522 · Cited by 50
Effects of combined knee loadings on posterior cruciate ligament force generation
Markolf, K. L., Slauterbeck, J. L., Armstrong, K. L., Shapiro, M. M., & Finerman, G. A. M. (1996) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100140419 · Cited by 38
Self-citationMarkolf, K. L., Willems, M. J., Jackson, S. R., & Finerman, G. A. M. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160410 · Cited by 32
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Mechanisms of Anterior Cruciate Ligament Injury in Basketball: Video Analysis of 39 Cases
Krosshaug, T., Nakamae, A., Boden, B. P., Engebretsen, L., Smith, G., Slauterbeck, J. R., Hewett, T. E., & Bahr, R. (2007) · The American Journal of Sports Medicine · doi:10.1177/0363546506293899 · Cited by 1,212
Mechanisms of Noncontact Anterior Cruciate Ligament Injury
Shimokochi, Y., & Shultz, S. J. (2008) · Journal of Athletic Training · doi:10.4085/1062-6050-43.4.396 · Cited by 472
The Effect of Angle and Velocity on Change of Direction Biomechanics: An Angle-Velocity Trade-Off
Dos’Santos, T., THOMAS, C. R., Comfort, P., & Jones, P. A. (2018) · Sports Medicine · doi:10.1007/s40279-018-0968-3 · Cited by 407
The Effect of Technique Change on Knee Loads during Sidestep Cutting
Dempsey, A. R., Lloyd, D. G., Elliott, B. C., Steele, J. R., Munro, B. J., & Russo, K. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31812f56d1 · Cited by 288
The anterior cruciate ligament injury controversy: is “valgus collapse” a sex-specific mechanism?
Quatman, C. E., & Hewett, T. E. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.059139 · Cited by 260
Metadata
- Authors
- Markolf, K. L., O'Neill, G., Jackson, S. R., & McAllister, D. R.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 2004-07
- Volume
- 32
- Issue
- 5
- Pages
- 1144-1149
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2118040773
- Cited by
- 229
- References
- 16
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 13 · 2021: 20 · 2020: 13 · 2019: 10 · 2018: 12 · 2017: 15 · 2016: 14 · 2015: 8 · 2014: 4 · 2013: 10 · 2012: 15
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Physical Sciences › Engineering › Biomedical Engineering › Lower Extremity Biomechanics and Pathologies
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Keywords
- anterior cruciate ligament, posterior cruciate ligament, knee flexion angle, tibial translation, ligament healing
- MeSH terms
- Adult, Aged, Biomechanical Phenomena, Cadaver, Female, Humans, Knee Joint, Male, Middle Aged, Tendons, Range of Motion, Articular, Anterior Cruciate Ligament, Posterior Cruciate Ligament, Weight-Bearing, Muscle, Skeletal, Torque
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