The DOI matches its Crossref record, with a small difference in title or year; 62 of the 62 references it cites were found in a registry or an index.
Medial collateral ligament healing: A multidisciplinary assessment in rabbits
Abstract
Medial collateral ligament healing without treatment has been studied in a rabbit model. Complete midsubstance gaps were found to heal by distinct scar formation over time. This healing process was fast since the gap was bridged quickly; however, more subtle changes in ap pearance of the healing tissue continued for many months. The ligament "scar" was found to be structur ally abnormal chemically and mechanically even at long- term followup. A plateau in its improvement suggests that the scar may never approach normal ligament characteristics (without treatment). A baseline of liga ment healing by scar formation has been established.
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“As ligament laxity persists, the affected joint and other structures in and around the knee joint are exposed to the risk of further damage [44,45].”
From Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint (2023) · cites this paper as [45]
Citations
Cites
Woessner, J. F. (1961) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(61)90291-0 · Cited by 3,849
A colorimetric method for the determination of glucosamine and chondrosamine
Elson, L. A., & Morgan, W. T. J. (1933) · Biochemical Journal · doi:10.1042/bj0271824 · Cited by 1,781
METHOD FOR THE DETERMINATION OF HEXOSAMINES IN TISSUES
Boas, N. F. (1953) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66055-7 · Cited by 1,530
The strength of the anterior cruciate ligament in humans and Rhesus monkeys
Noyes, F. R., & Grood, E. S. (1976) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197658080-00006 · Cited by 826
Classification of knee ligament instabilities. Part I. The medial compartment and cruciate ligaments
Hughston, J. C., Andrews, J., Cross, M., & Moschi, A. (1976) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197658020-00001 · Cited by 810
Anterior and posterior cruciate ligament reconstruction in rhesus monkeys.
Clancy, W. G., Narechania, R. G., Rosenberg, T. D., Gmeiner, J. G., Wisnefske, D. D., & Lange, T. A. (1981) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-198163080-00008 · Cited by 702
Biomechanics of Anterior Cruciate Ligament Failure
Noyes, F. R., Delucas, J. L., & Torvik, P. J. (1974) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197456020-00002 · Cited by 659
Chemistry and molecular biology of the intercellular matrix
Balazs, E. A. (1970) · Academic Press eBooks · Cited by 624
Cooper, R. R., Misol, S., & Stimmel, P. (1970) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197052010-00001 · Cited by 514
THE FIBROBLAST AND WOUND REPAIR
Ross, R. (1968) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1968.tb01109.x · Cited by 440
THE RATE OF HEALING OF TENDONS* AN EXPERIMENTAL STUDY OF TENSILE STRENGTH
Mason, M. L., & Allen, H. S. (1941) · Annals of Surgery · doi:10.1097/00000658-194103000-00009 · Cited by 416
In vivo knee stability. A quantitative assessment using an instrumented clinical testing apparatus.
Markolf, K. L., Graff‐Radford, A., & Amstutz, H. C. (1978) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197860050-00014 · Cited by 399
Mechanical properties of tendons and ligaments
Woo, S. L. (1982) · Biorheology · doi:10.3233/bir-1982-19301 · Cited by 380
Self-citationChemical and Histochemical Sequences in the Normal Healing of Wounds
Dunphy, J. E., & Udupa, K. N. (1955) · New England Journal of Medicine · doi:10.1056/nejm195511172532002 · Cited by 364
The Natural History and Diagnosis of Anterior Cruciate Ligament Insufficiency
Fetto, J. F., & MARSHALL, J. L. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198003000-00006 · Cited by 341
SURGICAL TREATMENT OF FRESH INJURIES TO THE MAJOR LIGAMENTS OF THE KNEE
OʼDonoghue, D. H. (1950) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195032040-00001 · Cited by 274
Surgical treatment of fresh injuries to the major ligaments of the knee.
OʼDonoghue, D. H. (1950) · PubMed · Cited by 268
An analysis of end results of surgical treatment of major injuries to the ligaments of the knee.
OʼDonoghue, D. H. (1955) · PubMed · Cited by 257
Repair of the Anterior Cruciate Ligament in Dogs
OʼDonoghue, D. H., Rockwood, C. A., Frank, G. R., JACK, S. C., & Kenyon, R. (1966) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-196648030-00009 · Cited by 242
The influence of physical activity on ligaments and tendons
Tipton, C. M., MATTHES, R. D., Maynard, J. A., & Carey, R. A. (1975) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-197500730-00014 · Cited by 239
AN ANALYSIS OF END RESULTS OF SURGICAL TREATMENT OF MAJOR INJURIES TO THE LIGAMENTS OF THEe KNEE
OʼDonoghue, D. H. (1955) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-195537010-00001 · Cited by 237
Medial and Anterior Instability of the Knee
Kennedy, J. C., & Fowler, P. J. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153070-00001 · Cited by 222
Kennedy, J. C., & Fowler, P. J. (1995) · PubMed · Cited by 210
Instability of the knee. A long-term experimental study in dogs.
Marshall, J. L., & Olsson, S. (1971) · PubMed · Cited by 205
Influence of Physical Activity on Ligament Insertions in the Knees of Dogs
Laros, G. S., Tipton, C. M., Cooper, R. R., Stimmel, P., Davis, R., & MATTHES, R. D. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153020-00007 · Cited by 198
Influence of exercise on strength of medial collateral knee ligaments of dogs
Tipton, C. M., James, S. L., Mergner, W., & Tcheng, T. (1970) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1970.218.3.894 · Cited by 190
Minns, R. J., Soden, P. D., & Jackson, D. S. (1973) · Journal of Biomechanics · doi:10.1016/0021-9290(73)90084-5 · Cited by 189
Akeson, W. H., Amiel, D., Mechanic, G. L., Woo, S. L., Harwood, F. L., & Hamer, M. L. (1977) · Connective Tissue Research · doi:10.3109/03008207709152607 · Cited by 184
Self-citationOʼDonoghue, D. H., Frank, G. R., JETER, G. L., Johnson, W. R., ZEIDERS, J. W., & Kenyon, R. (1971) · PubMed · Cited by 179
MARSHALL, J. L., & Olsson, S. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153080-00008 · Cited by 179
Repair and Reconstruction of the Anterior Cruciate Ligament in Dogs
OʼDonoghue, D. H., FRANK, G. R., JETER, G. L., Johnson, W. D., ZEIDERS, J. W., & Kenyon, R. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153040-00010 · Cited by 158
Experimental studies of acute anterior cruciate ligament injury and repair
Cabaud, H. E., Rodkey, W. G., & Feagin, J. A. (1979) · The American Journal of Sports Medicine · doi:10.1177/036354657900700105 · Cited by 157
Ellsasser, J. C., Reynolds, F. C., & OMOHUNDRO, J. R. (1974) · PubMed · Cited by 157
Ellsasser, J. C., REYNOLDS, F. C., & OMOHUNDRO, J. R. (1974) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197456060-00009 · Cited by 148
Determination of microgram quantities of deoxyribonucleic acid and protein in tissues grown in vitro
BONTING, S. L., & Jones, M. (1957) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(57)80009-5 · Cited by 147
Physical Activity and its Influence on the Repair Process of Medial Collateral Ligaments
VAILAS, A. C., Tipton, C. M., MATTHES, R. D., & Gart, M. (1981) · Connective Tissue Research · doi:10.3109/03008208109160237 · Cited by 133
Vogel, H. G. (1978) · Connective Tissue Research · doi:10.3109/03008207809152626 · Cited by 133
Cell morphology and collagen types in equine tendon scar
Williams, I. F., Heaton, A., & McCullagh, K. G. (1980) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)32713-9 · Cited by 131
Buck, R. C. (1953) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700660103 · Cited by 110
Changes in the nature of the collagen during development and resorption of granulation tissue
Bailey, A. J., Bazin, S., & Delaunay, A. N. (1973) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(73)90272-9 · Cited by 102
The Non-Operative Management of Collateral Ligament Injuries of the Knee Joint
Hastings, D. E. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198003000-00005 · Cited by 101
Digital flexor tendons: An experimental study
Lindsay, W. K., Thomson, H. G., & Walker, F. G. (1960) · British Journal of Plastic Surgery · doi:10.1016/s0007-1226(60)80003-3 · Cited by 95
The canine stifle joint I. Rupture of the anterior cruciate ligament
Pond, M. J., & Campbell, J. R. (1972) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.1972.tb06791.x · Cited by 86
Experimental investigations of ligamentous healing
Clayton, M. L., & Weir, G. J. (1959) · The American Journal of Surgery · doi:10.1016/0002-9610(59)90529-x · Cited by 85
EXPERIMENTAL RUPTURE OF THE MEDIAL COLLATERAL LIGAMENT OF THE KNEE
Jack, E. A. (1950) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.32b3.396 · Cited by 73
Experimental Investigations of Ligamentous Healing
Clayton, M. L., MILES, J. S., & ABDULLA, M. (1968) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196811000-00014 · Cited by 72
Experimental Investigations of Ligamentous Healing
Clayton, M. L., MILES, J. S., & ABDULLA, M. (1968) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-196800610-00014 · Cited by 66
Contraction and the control of contraction
Rudolph, R. (1980) · World Journal of Surgery · doi:10.1007/bf02393383 · Cited by 64
Collagen reduction by sodium borohydride: Effects of reconstitution, maturation and lathyrism
Tanzer, M. L., & Mechanic, G. L. (1968) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(68)90324-0 · Cited by 59
Repair of Knee Ligaments in Dogs
OʼDonoghue, D. H., Rockwood, C. A., Zaricznyj, B., & Kenyon, R. (1961) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-196143080-00008 · Cited by 44
Mucopolysaccharides, Collagen, and Nonfibrillar Proteins in Inflammation
Delaunay, A., & Bazin, S. (1964) · International review of connective tissue research · doi:10.1016/b978-1-4831-6751-0.50013-6 · Cited by 42
Knee Sprains and Acute Knee Hemarthrosis
Noyes, F. R., Paulos, L. E., Mooar, L. A., & Signer, B. (1980) · Physical Therapy · doi:10.1093/ptj/60.12.1596 · Cited by 27
Miltner, L. J. (1937) · Archives of Surgery · doi:10.1001/archsurg.1937.01190140026002 · Cited by 24
Wound healing of tendon—I. Physical, mechanical and metabolic changes
Goldin, B., Block, W. D., & Pearson, J. R. (1980) · Journal of Biomechanics · doi:10.1016/0021-9290(80)90367-x · Cited by 23
Noyes, F. R., Grood, E. S., Butler, D. L., & Raterman, L. (1980) · Physical Therapy · doi:10.1093/ptj/60.12.1578 · Cited by 22
Secondary Wound Tensile Strength Gain
Bryant, W. M., & Weeks, P. M. (1967) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-196701000-00011 · Cited by 20
Experimental Reproduction of Joint Sprains
Miltner, L. J., & Hu, C. (1933) · Experimental Biology and Medicine · doi:10.3181/00379727-30-6721 · Cited by 16
Frank, C., Beaver, P., Rademaker, F., Becker, K., Schachar, N. S., & Edwards, G. (1982) · PubMed · Cited by 15
Self-citationClinical and Pathologic Evaluation of Ruptured Cranial Cruciate Ligament Repair in the Dog
McCurnin, D. M., Pearson, P. T., & Wass, W. M. (1971) · American Journal of Veterinary Research · doi:10.2460/ajvr.1971.32.10.1517 · Cited by 15
Experimental repair of the medial collateral ligament of the knee in rabbits.
Fukubayashi, T., Kondo, M., Nakajima, H., Suzuki, K., & Miyanaga, Y. (1980) · PubMed · Cited by 12
Jackson, D. S., & Mechanic, G. L. (1974) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(74)90400-0 · Cited by 8
Rehabilitation of the unstable knee.
Rj, J., & Eriksson, E. (1982) · PubMed · Cited by 7
Research works printed but not linked: 3
- Grillo HC Aspects of the ongin, synthesis and evaluation of fibrous tissue in repair In Montagna W, Billingham RE (ed) Advances in Biology of Skin, Wound Healing , New York, Pergamon Press, 1964, pp 128-143
- Madden JW Wound healing Biologic and clinical features. In Sabiston DC (ed): Textbook of Surgery-The Biological Basis of Modern Surgical Practice Philadelphia , WB Saunders, 1972, p 262
- Peacock EE Jr, Van Winkle W. Jr The biochemistry and the environment of wounds and their relation to wound strength In Peacock EE, Van Winkle W (ed) Surgery and Biology of Wound Repair Philadelphia, WB Saunders , 1970, pp 129-130
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Awad, H. A., Butler, D. L., Boivin, G. P., Smith, F. N. L., Malaviya, P., Huibregtse, B. A., & Caplan, A. I. (1999) · Tissue Engineering · doi:10.1089/ten.1999.5.267 · Cited by 543
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Metadata
- Authors
- Frank, C., Woo, S. L.-Y., Amiel, D., Harwood, F., Gomez, M., & Akeson, W.
- Affiliations
- University of California San Diego (US)
- United States Department of Veterans Affairs (US)
- ORCID
- Amiel, D.
- Venue
- The American Journal of Sports Medicine
- Publisher
- SAGE Publications
- Published
- 1983-11
- Volume
- 11
- Issue
- 6
- Pages
- 379-389
- ISSN
- 0363-5465 (ISSN-L)
- 1552-3365
- OpenAlex
- W2052694074
- Cited by
- 367
- References
- 62
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 10 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 5 · 2014: 8 · 2013: 16 · 2012: 8
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Tendon Structure and Treatment
- Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports injuries and prevention
- Keywords
- medial collateral ligament, ligament healing, scar formation, rabbit model, ligament biomechanics
- MeSH terms
- Animals, Biomechanical Phenomena, Body Water, Cicatrix, Collagen, DNA, Glycosaminoglycans, Knee Joint, Ligaments, Articular, Male, Rabbits, Wound Healing
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